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Symbol
Name
ID
Sox2
SRY (sex determining region Y)-box 2
MGI:98364
Phenotype annotations related to endocrine/exocrine glands
Darker colors indicate more annotations
Human Phenotypes
Adrenal hypoplasia
Adrenal insufficiency
Abnormality of the hypothalamus-pituitary axis
Anterior pituitary hypoplasia
Anterior hypopituitarism
Ectopic posterior pituitary
Hypothyroidism
Female hypogonadism
Hypogonadotrophic hypogonadism
Disease(s) Associated with SOX2
microphthalmia

Mouse Phenotypes
abnormal salivary gland morphology
abnormal Ebner's gland morphology
absent anterior lingual gland
absent palatine gland
abnormal pituitary gland morphology
abnormal adenohypophysis development
bifurcated Rathke's pouch
decreased somatotroph cell number
small adenohypophysis
abnormal seminiferous tubule morphology
small testis
Availability Mouse Genotype
Sox2tm1Rlb/Sox2+
Sox2tm2Lpev/Sox2tm3Lpev
Sox2tm3(TK)Hoch/Sox2+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory