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Symbol
Name
ID
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations

Mouse Phenotypes
decreased T cell proliferation
decreased thymocyte number
decreased DN4 thymocyte number
abnormal common myeloid progenitor cell morphology
abnormal erythropoiesis
decreased double-negative T cell number
decreased double-positive T cell number
extramedullary hematopoiesis
increased megakaryocyte cell number
increased neutrophil cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased gamma-delta T cell number
increased leukocyte cell number
increased spleen red pulp amount
enlarged spleen
Availability Mouse Genotype
Sos1tm1.2Rak/Sos1+
Sos1tm1.1Les/Sos1tm1.1Les
Tg(Lck-cre)1Cwi/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory