Symbol
Name
ID

Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes

High anterior hairline

Low posterior hairline

Micrognathia

Macrocephaly

Triangular face

Midface retrusion

High forehead

Thick lower lip vermilion

Thick vermilion border

Gingival fibromatosis

Gingival overgrowth

High palate

Wide mouth

Dental malocclusion

Depressed nasal bridge

Sparse eyebrow

Downslanted palpebral fissures

Epicanthus

Disease(s) Associated with SOS1

gingival fibromatosis

Noonan syndrome

Noonan syndrome 4

Mouse Phenotypes		abnormal craniofacial morphology	decreased cranium height	abnormal frontal bone morphology	cleft palate
Availability	Mouse Genotype	abnormal craniofacial morphology	decreased cranium height	abnormal frontal bone morphology	cleft palate
	Sos1^tm1.2Rak/Sos1^tm1.2Rak
	Sos1^tm1Dlb/Sos1^tm1Dlb
	Sos1^tm1.2Rak/Sos1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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