|
Symbol Name ID |
Sod2
superoxide dismutase 2, mitochondrial MGI:98352 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Intracellular accumulation of autofluorescent lipopigment storage material |
Fingerprint intracellular accumulation of autofluorescent lipopigment storage material |
Hypercalcemia |
Decreased level of 1,5 anhydroglucitol in serum |
Elevated circulating creatinine concentration |
Elevated circulating creatine kinase concentration |
Hyperproteinemia |
Elevated circulating hepatic transaminase concentration |
Hyperglycemia |
Diabetes mellitus |
Type II diabetes mellitus |
Insulin resistance |
Ketoacidosis |
Peau d'orange |
Pleural effusion |
Fever |
Abnormality of vitamin B12 metabolism |
Hepatic steatosis |
Hematuria |
Pyuria |
Increased level of L-fucose in urine |
Proteinuria |
Amyloidosis |
Medial calcification of large arteries |
Medial calcification of medium-sized arteries |
Cerebral calcification |
Calcification of falx cerebri |
| Disease(s) Associated with SOD2 | |||||||||||||||||||||||||||||||
| inclusion body myositis | |||||||||||||||||||||||||||||||
| metabolic dysfunction-associated steatotic liver disease | |||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||
| neuronal ceroid lipofuscinosis | |||||||||||||||||||||||||||||||
| pancreatic cancer | |||||||||||||||||||||||||||||||
| pseudoxanthoma elasticum | |||||||||||||||||||||||||||||||
| stomach cancer | |||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||
| type 1 diabetes mellitus | |||||||||||||||||||||||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
impaired exercise endurance |
decreased aerobic running capacity |
increased cardiac muscle glycogen level |
abnormal blood homeostasis |
abnormal blood gas level |
abnormal blood pH regulation |
increased blood urea nitrogen level |
decreased circulating glucose level |
increased circulating ketone body level |
decreased circulating lactate level |
increased circulating alkaline phosphatase level |
increased circulating aspartate transaminase level |
decreased body surface temperature |
abnormal enzyme/coenzyme level |
hypocapnia |
hyperoxia |
calcinosis |
abnormal lipid homeostasis |
acidosis |
metabolic acidosis |
abnormal urine homeostasis |
organic aciduria |
abnormal enzyme/coenzyme activity |
delayed wound healing |
enhanced wound healing |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Sod2tm1Cje/Sod2tm1Cje | ! | ! | ! | ! | ! | ! | ! | ! | ! | ||||||||||||||||||
| Sod2tm1Leb/Sod2tm1Leb | |||||||||||||||||||||||||||
| Sod2tm1Shs/Sod2tm1Shs Tg(TNNI2-icre)1Vrmn/0 (conditional) |
* | ||||||||||||||||||||||||||
| Sod2tm1Shs/Sod2tm1Shs Tg(Cdh16-cre)91Igr/0 (conditional) |
* | ||||||||||||||||||||||||||
| Sod2tm1Shs/Sod2tm1Shs Tg(Ckmm-cre)5Khn/0 (conditional) |
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| Sod2tm1Smel/Sod2tm1Smel Tg(KRT14-cre/ERT)20Efu/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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