Symbol
Name
ID

Shh
sonic hedgehog
MGI:98297

Phenotype annotations related to growth/size/body

Darker colors indicate more annotations

Human Phenotypes	Branchial anomaly	Short neck	Omphalocele	Congenital diaphragmatic hernia	Short stature	Failure to thrive in infancy	Weight loss
Disease(s) Associated with SHH	Branchial anomaly	Short neck	Omphalocele	Congenital diaphragmatic hernia	Short stature	Failure to thrive in infancy	Weight loss
Hirschsprung's disease
holoprosencephaly
hypoplastic or aplastic tibia with polydactyly
solitary median maxillary central incisor

Mouse Phenotypes

absent alveolar process

abnormal odontoblast morphology

abnormal incisor morphology

abnormal lower incisor morphology

small incisors

abnormal molar cusp morphology

small molars

abnormal ameloblast morphology

absent enamel cord

arrest of tooth development

growth retardation of incisors

growth retardation of molars

abnormal dentin morphology

abnormal enamel morphology

abnormal maxillary shelf morphology

abnormal nasal bone morphology

abnormal palatal shelf fusion at midline

palatal shelves fail to meet at midline

palatal shelf hypoplasia

cleft secondary palate

embryonic growth retardation

decreased embryo size

decreased lean body mass

decreased body weight

lung cyst

microcephaly

acephaly

decreased body size

postnatal growth retardation

abnormal prenatal growth/weight/body size

decreased fetal size

fetal growth retardation

Availability

Mouse Genotype

Shh^{tm1(EGFP/cre)Cjt}/Shh^{tm1(EGFP/cre)Cjt}

Shh^tm1.1Rseg/Shh^tm1.1Rseg

Shh^tm1Amc/Shh^tm1Amc

Shh^tm1Chg/Shh^tm1Chg

Shh^tm1Ptch/Shh^tm1Ptch

Shh^tm3(cre)Chg/Shh^tm3(cre)Chg

Shh^tm1Amc/Shh^tm1.1Rseg

Shh^{tm1b(EUCOMM)Wtsi}/Shh⁺

Shh^tm2Amc/Shh^tm2Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Shh^tm2Amc/Shh^tm2Amc
Tg(Nes-cre)1Kln/0 (conditional)

Shh^tm2Chg/Shh⁺
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Shh^tm1Amc/Shh^tm2Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Shh^tm1Amc/Shh^tm2Amc
Tg(KRT14-cre)1Amc/0 (conditional)

Shh^tm1Amc/Shh^tm2Amc
Tg(Thy1-cre)703Vaw/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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