|
Symbol Name ID |
Shh
sonic hedgehog MGI:98297 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal skull morphology |
Frontal bossing |
Flat occiput |
Hypoplasia of the zygomatic bone |
Malar flattening |
Dandy-Walker malformation |
Microcephaly |
Macrocephaly |
Encephalocele |
Abnormal facial shape |
Midface retrusion |
Broad philtrum |
Deep philtrum |
Cleft upper lip |
Median cleft upper lip |
Bilateral cleft lip |
Cleft lip |
Torus palatinus |
Bifid uvula |
Cleft palate |
Median cleft palate |
Prominent median palatal raphe |
Solitary median maxillary central incisor |
Tooth agenesis |
Abnormality of the nose |
Choanal atresia |
Short columella |
Anteverted nares |
Depressed nasal ridge |
Depressed nasal tip |
Depressed nasal bridge |
Midnasal stenosis |
Absent nares |
Single naris |
Aplasia/Hypoplasia involving the nose |
Proboscis |
Pyriform aperture stenosis |
Abnormal nasopharynx morphology |
Anosmia |
Hyposmia |
Highly arched eyebrow |
Synophrys |
Thick eyebrow |
Blepharophimosis |
Upslanted palpebral fissure |
Epicanthus |
| Disease(s) Associated with SHH | ||||||||||||||||||||||||||||||||||||||||||||||
| holoprosencephaly | ||||||||||||||||||||||||||||||||||||||||||||||
| holoprosencephaly 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| solitary median maxillary central incisor |
| Mouse Phenotypes | abnormal craniofacial morphology |
abnormal craniofacial bone morphology |
abnormal cranium morphology |
abnormal neurocranium morphology |
absent alveolar process |
abnormal odontoblast morphology |
abnormal incisor morphology |
abnormal lower incisor morphology |
small incisors |
abnormal molar cusp morphology |
small molars |
abnormal ameloblast morphology |
absent enamel cord |
arrest of tooth development |
growth retardation of incisors |
growth retardation of molars |
abnormal dentin morphology |
abnormal enamel morphology |
abnormal maxillary shelf morphology |
abnormal nasal bone morphology |
abnormal nasal pit morphology |
abnormal palatal shelf fusion at midline |
palatal shelves fail to meet at midline |
palatal shelf hypoplasia |
cleft secondary palate |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||
| Shhtm1Chg/Shhtm1Chg | ||||||||||||||||||||||||||
| Shhtm3(cre)Chg/Shhtm3(cre)Chg | ||||||||||||||||||||||||||
| Shhtm2Chg/Shh+ Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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| Shhtm1Amc/Shhtm2Amc Tg(KRT14-cre)1Amc/0 (conditional) |
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| Shhtm1Amc/Shhtm2Amc Tg(Thy1-cre)703Vaw/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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