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Symbol
Name
ID
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
MGI:98282
Phenotype annotations related to immune system
Darker colors indicate more annotations

Mouse Phenotypes
abnormal granulocyte differentiation
abnormal neutrophil differentiation
abnormal macrophage differentiation
small thymus
decreased thymocyte number
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal leukopoiesis
abnormal B cell differentiation
decreased pro-B cell number
arrested B cell differentiation
abnormal T cell differentiation
abnormal double-negative T cell morphology
decreased double-negative T cell number
increased double-negative T cell number
decreased double-positive T cell number
abnormal myelopoiesis
failure of myelopoiesis
impaired myelopoiesis
abnormal granulocyte morphology
decreased neutrophil cell number
increased neutrophil cell number
decreased granulocyte number
increased granulocyte number
abnormal B cell number
decreased mature B cell number
absent mature B cells
decreased B-1a cell number
increased B-1 B cell number
increased B-1b cell number
decreased B cell number
absent B cells
decreased pre-B cell number
abnormal T cell subpopulation ratio
abnormal T cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased T cell number
increased T cell number
increased lymphocyte cell number
decreased macrophage cell number
abnormal microglial cell morphology
abnormal monocyte morphology
abnormal spleen morphology
decreased spleen red pulp amount
increased IgM level
sepsis
Availability Mouse Genotype
Spi1tm1.1Dgt/Spi1tm1.1Dgt
Spi1tm1.3Dgt/Spi1tm1.3Dgt
Spi1tm1Kast/Spi1tm1Kast
Spi1tm1Ram/Spi1tm1Ram
Spi1tm1Rpd/Spi1tm1Rpd
Spi1tm1Sing/Spi1tm1Sing
Spi1tm3Dgt/Spi1tm3Dgt
Spi1tm1.2Nutt/Spi1tm1.2Nutt
Tg(Mx1-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory