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Symbol
Name
ID
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
MGI:98282
Phenotype annotations related to hematopoietic system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
hematopoietic system phenotype
abnormal granulocyte differentiation
abnormal neutrophil differentiation
abnormal macrophage differentiation
increased hematopoietic stem cell proliferation
small thymus
decreased thymocyte number
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal blood cell morphology/development
abnormal definitive hematopoiesis
abnormal common myeloid progenitor cell morphology
absent common myeloid progenitor cells
abnormal erythropoiesis
abnormal leukopoiesis
abnormal B cell differentiation
decreased pro-B cell number
arrested B cell differentiation
abnormal T cell differentiation
abnormal double-negative T cell morphology
decreased double-negative T cell number
increased double-negative T cell number
decreased double-positive T cell number
abnormal myelopoiesis
failure of myelopoiesis
impaired myelopoiesis
extramedullary hematopoiesis
anemia
abnormal bone marrow cell morphology/development
increased bone marrow cell number
abnormal proerythroblast morphology
abnormal erythrocyte cell number
abnormal fetal derived definitive erythrocyte cell number
absent erythrocytes
decreased hematocrit
abnormal granulocyte morphology
decreased neutrophil cell number
increased neutrophil cell number
decreased granulocyte number
increased granulocyte number
abnormal B cell number
decreased mature B cell number
absent mature B cells
decreased B-1a cell number
increased B-1 B cell number
increased B-1b cell number
decreased B cell number
absent B cells
decreased pre-B cell number
abnormal T cell subpopulation ratio
abnormal T cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased T cell number
increased T cell number
increased lymphocyte cell number
decreased macrophage cell number
decreased hematopoietic stem cell number
increased hematopoietic stem cell number
abnormal microglial cell morphology
abnormal monocyte morphology
abnormal spleen morphology
decreased spleen red pulp amount
abnormal hematopoietic system physiology
increased IgM level
abnormal hematopoietic stem cell physiology
Availability Mouse Genotype
Spi1tm1.1Dgt/Spi1tm1.1Dgt
Spi1tm1.1Nutt/Spi1tm1.1Nutt
Spi1tm1.1Rpd/Spi1tm1.1Rpd
Spi1tm1.3Dgt/Spi1tm1.3Dgt
Spi1tm1.3Nutt/Spi1tm1.3Nutt
Spi1tm1Kast/Spi1tm1Kast
Spi1tm1Ram/Spi1tm1Ram
Spi1tm1Rpd/Spi1tm1Rpd
Spi1tm1Sing/Spi1tm1Sing
Spi1tm2.1Dgt/Spi1tm2.1Dgt
Spi1tm2Dgt/Spi1tm2Dgt
Spi1tm3Dgt/Spi1tm3Dgt
Spi1tm4.1Dgt/Spi1tm4.1Dgt *
Spi1tm1Kast/Spi1+
Spi1tm1.2Nutt/Spi1tm1.2Nutt
Tg(Mx1-cre)1Cgn/0  (conditional)
Spi1tm2Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Spi1tm2Dgt/Spi1tm2Dgt  (conditional)
*
Spi1tm2.1Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory