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Symbol
Name
ID
Ret
ret proto-oncogene
MGI:97902
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Cerebral hemorrhage
Abnormality of enteric ganglion morphology
Aganglionic megacolon
Pheochromocytoma
Abnormality of the nervous system
Ganglioneuroma
Neoplasm of the central nervous system
Neuroblastoma
Ganglioneuroblastoma
Cognitive impairment
Headache
Intellectual disability
Global developmental delay
Seizures
Abnormality of the autonomic nervous system
Disease(s) Associated with RET
congenital central hypoventilation syndrome
Hirschsprung's disease
multiple endocrine neoplasia type 2A
multiple endocrine neoplasia type 2B
pheochromocytoma

Mouse Phenotypes
nervous system phenotype
decreased neuron apoptosis
increased neuron apoptosis
abnormal neuron differentiation
abnormal enteric neural crest cell morphology
absent enteric neural crest cell
adrenergic chromaffin cell hyperplasia
abnormal muscle spindle morphology
increased ganglioneuroma incidence
abnormal enteric nervous system morphology
abnormal enteric ganglia morphology
abnormal enteric neuron morphology
absent enteric neurons
abnormal cardiac ganglion morphology
abnormal pterygopalatine ganglion morphology
abnormal parasympathetic postganglionic fiber morphology
abnormal sympathetic ganglion morphology
abnormal stellate ganglion morphology
absent superior cervical ganglion
small superior cervical ganglion
abnormal prevertebral ganglion morphology
abnormal sympathetic neuron morphology
abnormal sympathetic postganglionic fiber morphology
abnormal hypoglossal nucleus morphology
abnormal facial motor nucleus morphology
abnormal innervation
abnormal innervation pattern to muscle
abnormal motor neuron innervation pattern
abnormal neuron morphology
loss of dopaminergic neurons
decreased motor neuron number
abnormal neuromuscular synapse morphology
small dorsal root ganglion
abnormal neurotransmitter secretion
abnormal synaptic dopamine release
Availability Mouse Genotype
Rettm1.1Ddg/Rettm1.1Ddg
Rettm1.1Kln/Rettm1.1Kln
Rettm1.2Pern/Rettm1.2Pern
Rettm1Cos/Rettm1Cos
Rettm1Cti/Rettm1Cti
Rettm1Giro/Rettm1Giro *
Rettm1Heno/Rettm1Heno
Rettm1Jmi/Rettm1Jmi
Rettm1Mat/Rettm1Mat
Rettm2.1Cos/Rettm2.1Cos
Rettm2.1Heno/Rettm2.1Heno
Rettm3(RET)Vpa/Rettm3(RET)Vpa
Rettm3Cos/Rettm3Cos
Rettm5(RET)Vpa/Rettm5(RET)Vpa
Rettm11(RET)Jmi/Rettm11(RET)Jmi *
Rettm12(RET)Jmi/Rettm12(RET)Jmi
Rettm13.1Jmi/Rettm13.1Jmi *
Rettm1Cos/Ret+
Rettm1Cti/Ret+
Rettm2(RET)Heno/Rettm3.1(Bcl2l1)Heno
Rettm2.1Cos/Ret+
Rettm3.1(Bcl2l1)Heno/Ret+ *
Rettm3.1(RET)Jmi/Ret+
Rettm11(RET)Jmi/Rettm12(RET)Jmi
Nkx6-2tm2(cre)Ercs/Nkx6-2+
Rettm1.1Pern/Rettm1.1Pern  (conditional)
Rettm1Ddg/Rettm1Ddg
H2afvTg(Wnt1-cre)11Rth/0  (conditional)
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0  (conditional)
Rettm1Kln/Rettm1Kln
Slc6a3tm1(cre)Xz/Slc6a3+  (conditional)
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno  (conditional)
*
Rettm1Heno/Rettm2(RET)Heno
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Rettm2(RET)Heno/Rettm1Cos
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Rettm13.1Jmi/Rettm13Jmi
Slc6a3tm1(cre)Xz/Slc6a3+  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory