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Symbol
Name
ID
Ret
ret proto-oncogene
MGI:97902
Phenotype annotations related to endocrine/exocrine glands
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Elevated calcitonin
Increased circulating cortisol level
Parathyroid adenoma
Parathyroid hyperplasia
Hyperparathyroidism
Nodular goiter
Neoplasm of the thyroid gland
Medullary thyroid carcinoma
Thyroid C cell hyperplasia
Pheochromocytoma
Disease(s) Associated with RET
familial medullary thyroid carcinoma
Hirschsprung's disease
multiple endocrine neoplasia type 2A
multiple endocrine neoplasia type 2B
pheochromocytoma

Mouse Phenotypes
abnormal submandibular gland morphology
endocrine/exocrine gland phenotype
abnormal adrenal gland morphology
adrenal cortical hyperplasia
abnormal adrenal medulla morphology
adrenergic chromaffin cell hyperplasia
abnormal thyroid gland morphology
thyroid gland hyperplasia
ectopic ovary
seminiferous tubule degeneration
cryptorchism
ectopic testis
increased pheochromocytoma incidence
increased thyroid adenoma incidence
Availability Mouse Genotype
Rettm1Cos/Rettm1Cos *
Rettm1Jmi/Rettm1Jmi
Rettm2.1Cos/Rettm2.1Cos
Rettm8(RET)Jmi/Rettm8(RET)Jmi
Rettm11(RET)Jmi/Rettm11(RET)Jmi
Rettm1Cos/Rettm2.1Cos *
Rettm1Giro/Ret+
Rettm2.1Cos/Ret+
Rettm3.1(RET)Jmi/Ret+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory