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Symbol
Name
ID
Prnp
prion protein
MGI:97769
Phenotype annotations related to muscle
Darker colors indicate more annotations
Human Phenotypes
Lower limb muscle weakness
Spasticity
Generalized hypotonia
Frequent falls
Disease(s) Associated with PRNP
Gerstmann-Straussler-Scheinker syndrome
Huntington's disease-like 1

Mouse Phenotypes
myoclonus
abnormal muscle fiber morphology
skeletal muscle fiber degeneration
abnormal skeletal muscle morphology
abnormal skeletal muscle fiber type ratio
muscle degeneration
muscular atrophy
abnormal muscle physiology
myopathy
Availability Mouse Genotype
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*)#Rgab/0
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0
Prnptm2.1Cwe/Prnptm2.1Cwe
Tg(Prnp*)#Rgab/0
Tg(Prnp*P101L)2866Sbp/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory