About   Help   FAQ
Symbol
Name
ID
Pparg
peroxisome proliferator activated receptor gamma
MGI:97747
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Splenomegaly
Pancreatitis
Disease(s) Associated with PPARG
familial partial lipodystrophy type 3

Mouse Phenotypes
immune system phenotype
abnormal osteoclast differentiation
increased B cell proliferation
impaired macrophage phagocytosis
abnormal T-helper 17 cell differentiation
decreased osteoclast cell number
abnormal osteoclast morphology
abnormal peritoneal macrophage morphology
abnormal spleen morphology
enlarged spleen
abnormal splenocyte morphology
increased splenocyte number
abnormal B cell physiology
increased IgG level
increased IgM level
abnormal macrophage physiology
abnormal macrophage activation involved in immune response
leukostasis
abnormal bone marrow development
abnormal humoral immune response
increased interferon-gamma secretion
increased interleukin-2 secretion
increased susceptibility to experimental autoimmune encephalomyelitis
increased susceptibility to induced arthritis
increased autoantibody level
increased anti-nuclear antigen antibody level
increased anti-double stranded DNA antibody level
increased anti-single stranded DNA antibody level
glomerulonephritis
skin inflammation
Availability Mouse Genotype
Ppargtm1Tka/Pparg+ *
Ppargtm1Wwah/Pparg+ *
Ppargtm1.1Gonz/Ppargtm1.1Gonz
Tg(Mx1-cre)1Cgn/?  (conditional)
Ppargtm1.1Gonz/Ppargtm1.1Gonz
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)1Ywa/?  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Krt1-15-cre/PGR)22Cot/?  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Cd4-cre)1Cwi/?  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)12Flv/?  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/11/2020
MGI 6.14
The Jackson Laboratory