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Symbol
Name
ID
Pparg
peroxisome proliferator activated receptor gamma
MGI:97747
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Decreased HDL cholesterol concentration
Hypertriglyceridemia
Hyperuricemia
Decreased resting energy expenditure
Hyperglycemia
Diabetes mellitus
Insulin-resistant diabetes mellitus
Maternal diabetes
Type II diabetes mellitus
Hyperinsulinemia
Insulin resistance
Disease(s) Associated with PPARG
familial partial lipodystrophy type 3
obesity
type 2 diabetes mellitus

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased susceptibility to diet-induced obesity
increased circulating creatine level
increased circulating glucose level
hyperglycemia
decreased circulating follicle stimulating hormone level
decreased circulating insulin level
increased circulating insulin level
decreased circulating leptin level
increased circulating leptin level
abnormal circulating aldosterone level
decreased circulating cholesterol level
increased circulating cholesterol level
decreased circulating free fatty acid level
increased circulating free fatty acid level
decreased circulating triglyceride level
increased circulating triglyceride level
hyperlipidemia
abnormal circulating alanine transaminase level
increased circulating aspartate transaminase level
decreased body temperature
increased body temperature
abnormal circadian temperature homeostasis
abnormal glucose homeostasis
impaired glucose tolerance
improved glucose tolerance
increased insulin sensitivity
insulin resistance
decreased circulating adiponectin level
increased circulating adiponectin level
increased luteinizing hormone level
abnormal urine sodium level
abnormal lipid homeostasis
abnormal triglyceride level
increased liver triglyceride level
increased triglyceride level
increased urine protein level
albuminuria
abnormal amino acid metabolism
abnormal physiological response to xenobiotic
increased sensitivity to xenobiotic induced morbidity/mortality
increased incidence of tumors by chemical induction
abnormal response to injury
Availability Mouse Genotype
Ppargtm1.1Auw/Ppargtm1.1Auw *
Ppargtm1.1Unc/Ppargtm1.1Unc *
Ppargtm1Auw/Ppargtm1Auw
Ppargtm1Laz/Ppargtm1Laz
Ppargtm1Yec/Ppargtm1Yec
Ppargtm2Avp/Ppargtm2Avp
Ppargtm1Avp/Pparg+ *
Ppargtm1Lja/Pparg+
Ppargtm1Mae/Pparg+
Ppargtm1Rev/Pparg+
Ppargtm1Tka/Pparg+
Ppargtm2(tTA)Yba/Pparg+ *
Ppargtm3(tTA)Yba/Pparg+
Ppargtm1.1Gonz/Ppargtm1.1Gonz
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Ppargtm1.1Gonz/Ppargtm1.1Gonz
Tg(Aqp2-cre)1Dek/0  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Fabp4-cre)1Rev/0  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)1Ywa/?  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Lhb-cre)1Sac/?  (conditional)
Ppargtm2Rev/Ppargtm2Rev
Tg(Ucp1-cre)1Evdr/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory