|
Symbol Name ID |
Por
cytochrome p450 oxidoreductase MGI:97744 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyperkalemia |
Hypokalemia |
Hyponatremia |
Hypoglycemia |
Hypokalemic alkalosis |
Fever |
Recurrent fever |
Renal salt wasting |
Increased circulating ACTH level |
Decreased circulating androstenedione concentration |
Increased circulating androstenedione concentration |
Decreased circulating dehydroepiandrosterone concentration |
Increased circulating dehydroepiandrosterone-sulfate concentration |
Increased serum testosterone level |
Increased circulating 17 hydroxypregnenolone concentration |
Decreased circulating progesterone |
Increased circulating progesterone |
Elevated circulating 17-hydroxyprogesterone concentration |
Decreased circulating cortisol level |
Elevated circulating 21-deoxycortisol concentration |
Elevated serum 11-deoxycortisol |
| Disease(s) Associated with POR | |||||||||||||||||||||
| Antley-Bixler syndrome with disordered steroidogenesis | |||||||||||||||||||||
| congenital adrenal hyperplasia | |||||||||||||||||||||
| cytochrome P450 oxidoreductase deficiency |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
pericardial edema |
increased circulating testosterone level |
decreased circulating progesterone level |
increased circulating progesterone level |
decreased circulating cholesterol level |
decreased circulating triglyceride level |
increased circulating alanine transaminase level |
abnormal enzyme/coenzyme level |
abnormal bile salt level |
abnormal enzyme/coenzyme activity |
abnormal acetaminophen metabolism |
abnormal xenobiotic pharmacokinetics |
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| Availability | Mouse Genotype | |||||||||||||
| Portm1Cbk/Portm1Cbk | ||||||||||||||
| Portm2Ding/Portm2Ding | ||||||||||||||
| Portm3Ding/Portm3Ding | ||||||||||||||
| Portm1Ding/Portm1Ding Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Portm1Wolf/Portm1Wolf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Portm3Ding/Portm3Ding Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
* | |||||||||||||
| Portm1Ding/Por+ Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Portm2Wolf/Portm1Wolf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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