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Symbol
Name
ID
Pomc
pro-opiomelanocortin-alpha
MGI:97742
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Pedal edema
Elevated circulating C-reactive protein concentration
Elevated circulating amyloid A concentration
Elevated erythrocyte sedimentation rate
Decreased resting energy expenditure
Pleural effusion
Fever
Recurrent fever
Proteinuria
Amyloidosis
Renal amyloidosis
Ascites
Disease(s) Associated with POMC
familial mediterranean fever
obesity

Mouse Phenotypes
homeostasis/metabolism phenotype
increased susceptibility to diet-induced obesity
increased circulating glucose level
decreased circulating adrenaline level
decreased circulating corticosterone level
increased circulating corticosterone level
increased circulating insulin level
increased circulating leptin level
decreased circulating aldosterone level
decreased circulating adrenocorticotropin level
decreased circulating thyroxine level
increased circulating interleukin-6 level
increased urine adrenaline level
increased dopamine level
decreased oxygen consumption
impaired glucose tolerance
insulin resistance
decreased adrenocorticotropin level
abnormal response/metabolism to endogenous compounds
increased physiological sensitivity to xenobiotic
Availability Mouse Genotype
Pomctm1.1Kgm/Pomctm1.1Kgm *
Pomctm1Low/Pomctm1Low *
Pomctm1Sora/Pomctm1Sora
Pomctm2Low/Pomctm2Low
Pomctm2Ute/Pomctm2Ute
Pomcem1(IMPC)Rbrc/Pomc+
Pomctm1Sora/Pomc+
Pomctm2Ute/Pomc+
Pomctm2Low/Pomctm2Low
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory