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Symbol
Name
ID
Plp1
proteolipid protein (myelin) 1
MGI:97623
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Dysphagia
Spasticity
Lower limb spasticity
Spastic paraparesis
Spastic paraplegia
Progressive spastic quadriplegia
Spastic gait
Abnormal CNS myelination
Cerebral dysmyelination
Sudanophilic leukodystrophy
Peripheral neuropathy
Sensory neuropathy
Cerebral cortical atrophy
Abnormal cerebellum morphology
Reduction of oligodendroglia
Spinocerebellar tract degeneration
Degeneration of the lateral corticospinal tracts
Ataxia
Dysmetria
Abnormality of extrapyramidal motor function
Abnormal pyramidal sign
Babinski sign
Cognitive impairment
Psychomotor deterioration
Intellectual disability
Neurological speech impairment
Dysarthria
Scanning speech
Abnormality of movement
Head titubation
Hyperreflexia
Hyporeflexia
Dystonia
Gait disturbance
Choreoathetosis
Tremor
Behavioral abnormality
Developmental regression
Delayed speech and language development
Global developmental delay
Seizures
Disease(s) Associated with PLP1
hereditary spastic paraplegia 2
Pelizaeus-Merzbacher disease

Mouse Phenotypes
nervous system phenotype
seizures
environmentally induced seizures
tonic-clonic seizures
abnormal oligodendrocyte apoptosis
abnormal microglial cell morphology
microgliosis
abnormal brain morphology
abnormal brain development
abnormal brain white matter morphology
abnormal cerebellum white matter morphology
abnormal optic tract morphology
abnormal hippocampal fimbria morphology
abnormal cerebellum morphology
abnormal cerebellar granule layer morphology
abnormal glial cell morphology
abnormal CNS glial cell morphology
abnormal astrocyte morphology
astrocytosis
abnormal oligodendrocyte morphology
decreased oligodendrocyte number
increased oligodendrocyte number
gliosis
abnormal axon morphology
abnormal myelin sheath morphology
decreased myelin sheath thickness
tomacula
abnormal optic nerve morphology
neurodegeneration
axon degeneration
axonal spheroids
abnormal astrocyte physiology
abnormal myelination
demyelination
dysmyelination
abnormal nerve conduction
decreased nerve conduction velocity
abnormal axonal transport
Availability Mouse Genotype
Plp1jp-msd/Plp1jp-msd
Plp1jp-rsh/Plp1jp-rsh
Plp1tm1Wst/Plp1tm1Wst
Plp1tm2Wst/Plp1tm2Wst
Plp1tm3Wst/Plp1tm3Wst
Tg(Plp)66Kan/Tg(Plp)66Kan
Tg(Plp)72Kan/Tg(Plp)72Kan
Plp1jp-rsh/Plp1+
Plp1jp/Plp1+
Plp1tm1Kan/Plp1+
Plp1tm1Wst/Plp1+
Plp1tm2Wst/Plp1+
Plp1jp-4J/Y
Plp1jp-msd/Y
Plp1jp-rsh/Y ! ! ! !
Plp1jp/Y
Plp1tm1.1Blyg/Y *
Plp1tm1.1Gow/Y
Plp1tm1Frca/Y
Plp1tm1Gow/Y
Plp1tm1Kan/Y
Tg(Plp)66Kan/0
Plp1tm1Kan/?
Plp1tm1c(EUCOMM)Wtsi/Y
Cnptm1(cre)Kan/Cnp+  (conditional)
Plp1tm1c(EUCOMM)Wtsi/Y
Neurod6tm1(cre)Kan/Neurod6+  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory