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Symbol
Name
ID
Plp1
proteolipid protein (myelin) 1
MGI:97623
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Behavioral abnormality
Disease(s) Associated with PLP1
Pelizaeus-Merzbacher disease

Mouse Phenotypes
behavior/neurological phenotype
abnormal startle reflex
tremors
ataxia
impaired coordination
paraparesis
hypoactivity
abnormal locomotor coordination
abnormal gait
hindlimb paralysis
decreased vocalization
seizures
environmentally induced seizures
tonic-clonic seizures
Availability Mouse Genotype
Plp1jp-rsh/Plp1jp-rsh *!
Plp1tm1Wst/Plp1tm1Wst
Plp1tm2Wst/Plp1tm2Wst
Tg(Plp)66Kan/Tg(Plp)66Kan
Plp1jp-4J/Y
Plp1jp-6J/Y
Plp1jp-msd/Y
Plp1jp-rsh/Y *! ! ! !
Plp1jp/Y
Plp1tm1.1Gow/Y
Plp1tm1Frca/Y *
Plp1tm1Gow/Y
Plp1tm1Kan/Y *
Tg(Plp)66Kan/0
Plp1tm1Kan/?

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory