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Symbol
Name
ID
Pkd1
polycystin 1, transient receptor poteintial channel interacting
MGI:97603
Phenotype annotations related to renal/urinary system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Polycystic kidney dysplasia
Renal insufficiency
Disease(s) Associated with PKD1
polycystic kidney disease 1

Mouse Phenotypes
renal/urinary system phenotype
increased kidney epithelial cell primary cilium length
increased kidney apoptosis
increased renal tubule apoptosis
increased kidney cell proliferation
abnormal kidney epithelial cell primary cilium physiology
decreased urine creatinine level
decreased urine osmolality
increased urine osmolality
decreased urine protein level
increased urine protein level
decreased urine urea nitrogen level
hematuria
kidney inflammation
increased renal hamartoma incidence
abnormal kidney morphology
abnormal kidney collecting duct morphology
abnormal renal glomerulus morphology
glomerulosclerosis
kidney cortex cysts
abnormal kidney epithelium morphology
abnormal renal tubule epithelium morphology
kidney epithelium hyperplasia
renal interstitial fibrosis
kidney medulla cysts
increased kidney weight
enlarged kidney
renal tubule atrophy
dilated proximal convoluted tubules
dilated renal tubules
renal cast
kidney cysts
polycystic kidney
renal glomerulus cysts
nephrocalcinosis
nephrolithiasis
pale kidney
renal fibrosis
abnormal kidney physiology
kidney failure
polyuria
Availability Mouse Genotype
Pkd1b2b1585Clo/Pkd1b2b1585Clo
Pkd1m1Bei/Pkd1m1Bei
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Pkd1tm1Bdgz/Pkd1tm1Bdgz
Pkd1tm1Djmp/Pkd1tm1Djmp
Pkd1tm1Ggg/Pkd1tm1Ggg
Pkd1tm1Hung/Pkd1tm1Hung
Pkd1tm1Jzh/Pkd1tm1Jzh *
Pkd1tm1Maa/Pkd1tm1Maa
Pkd1tm1Shh/Pkd1tm1Shh
Pkd1tm1Som/Pkd1tm1Som
Pkd1tm2.1Ggg/Pkd1tm2.1Ggg
Pkd1tm2.2Bol/Pkd1tm2.2Bol
Pkd1tm2Jzh/Pkd1tm2Jzh !
Pkd1tm3.1Jzh/Pkd1tm3.1Jzh
Pkd1tm3.2Bol/Pkd1tm3.2Bol
Pkd1tm1.2Djmp/Pkd1+
Pkd1tm1Bdgz/Pkd1+
Pkd1tm1Jzh/Pkd1+ *
Pkd1tm1Rsa/Pkd1+
Pkd1tm1Shh/Pkd1tm1.1Pcha
Pkd1tm1Som/Pkd1+
Pkd1tm1Som/Pkd1+
Tg(Pkd1*)39Mtru/0
Pkd1tm2Jzh/Pkd1+
Tg(Pkd1)6Mtru/0
Tg(Pkd1)18Mtru/0
Tg(Pkd1)26Mtru/0
Tg(Pkd1*)39Mtru/0
Pkd1tm1.1Djmp/Pkd1tm1.1Djmp
Tg(Cdh16-cre/ERT2)F427Djmp/0  (conditional)
Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+  (conditional)
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(MMTV-cre)4Mam/0  (conditional)
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Nes-cre)Wme/0  (conditional)
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Col1a1-cre)1Bek/0  (conditional)
Pkd1tm2Ggg/Pkd1tm2Ggg
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+  (conditional)
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Hoxb7-cre)13Amc/0  (conditional)
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0  (conditional)
Pkd1tm2Som/Pkd1tm2Som
Tg(Pkhd1-cre)1Igr/0  (conditional)
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Ggt1-cre)M3Egn/0  (conditional)
Pkd1tm3Jzh/Pkd1tm3Jzh  (conditional)
Pkd1tm3Jzh/Pkd1tm3Jzh
Tg(Col2a1-cre)10Amc/0  (conditional)
Pkd1tm1Ggg/Pkd1tm2Ggg
Meox2tm1(cre)Sor/Meox2+  (conditional)
Pkd1tm1.1Djmp/Pkd1tm1.2Djmp
Tg(Cdh16-cre/ERT2)F427Djmp/0  (conditional)
Pkd1tm1.1Pcha/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0  (conditional)
Pkd1tm2.2Bol/Pkd1tm3.1Bol
Tg(Nes-cre)1Kln/0  (conditional)
Pkd1tm2Ggg/Pkd1+
Tg(Col1a1-cre)1Bek/0  (conditional)
*
Pkd1tm2Som/Pkd1tm2.1Som
Tg(Cdh16-cre)91Igr/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory