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Symbol
Name
ID
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Diabetes mellitus
Decreased circulating ACTH level
Increased circulating cortisol level
Primary hypercortisolism
Paradoxical increased cortisol secretion on dexamethasone suppression test
Disease(s) Associated with PRKACA
primary pigmented nodular adrenocortical disease

Mouse Phenotypes
decreased insulin secretion
increased circulating glucose level
decreased circulating insulin level
increased circulating triglyceride level
abnormal glucose homeostasis
impaired glucose tolerance
abnormal glycogen homeostasis
decreased glycogen level
decreased urine protein level
abnormal enzyme/coenzyme activity
Availability Mouse Genotype
Prkacatm1Gsm/Prkacatm1Gsm
Tg(Camk2a-Prkaca)426Tabe/0
Prkacatm3Gsm/Prkacatm3Gsm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory