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Symbol
Name
ID
Pax8
paired box 8
MGI:97492
Phenotype annotations related to endocrine/exocrine glands
Darker colors indicate more annotations
Human Phenotypes
Increased thyroid-stimulating hormone level
Goiter
Ectopic thyroid
Thyroid agenesis
Thyroid hypoplasia
Hypothyroidism
Congenital hypothyroidism
Disease(s) Associated with PAX8
congenital nongoitrous hypothyroidism 2

Mouse Phenotypes
abnormal adenohypophysis morphology
decreased lactotroph cell number
decreased somatotroph cell number
increased thyrotroph cell number
abnormal thyroid gland morphology
abnormal thyroid follicle morphology
abnormal thyroid follicular cell morphology
absent thyroid follicular cells
abnormal thyroid gland development
abnormal thyroid diverticulum morphology
absent thyroid gland
small thyroid gland
absent efferent ductules of testis
decreased testis weight
testicular atrophy
decreased activity of thyroid gland
Availability Mouse Genotype
Pax8tm1(cre)Mbu/Pax8tm1(cre)Mbu
Pax8tm1Pgr/Pax8tm1Pgr
Pax8tm1Rdl/Pax8tm1.1(cre)Mbu  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory