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Symbol
Name
ID
Ntrk1
neurotrophic tyrosine kinase, receptor, type 1
MGI:97383
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Orthostatic hypotension due to autonomic dysfunction
Postural hypotension with compensatory tachycardia
Dysphagia
Difficulty walking
Painless fractures due to injury
Decreased number of small peripheral myelinated nerve fibers
Abnormality of peripheral nerve conduction
Sensory impairment
Pain insensitivity
Trophic limb changes
Distal sensory impairment
Impaired temperature sensation
Hyperesthesia
Intellectual disability
Abnormal emotion/affect behavior
Nail-biting
Self-mutilation
Hyperactivity
Impulsivity
Emotional lability
Short attention span
Global developmental delay
Specific learning disability
Abnormality of the autonomic nervous system
Abnormal autonomic nervous system physiology
Disease(s) Associated with NTRK1
hereditary sensory neuropathy type 4

Mouse Phenotypes
nervous system phenotype
increased muscle spindle number
abnormal sympathetic ganglion morphology
small superior cervical ganglion
abnormal innervation
abnormal sensory neuron innervation pattern
abnormal cholinergic neuron morphology
abnormal neurite morphology
decreased sensory neuron number
abnormal proprioceptive neuron morphology
small trigeminal ganglion
small dorsal root ganglion
abnormal sympathetic nervous system physiology
abnormal neuron physiology
abnormal sensory neuron physiology
Availability Mouse Genotype
Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo *
Ntrk1tm1.1Jcar/Ntrk1tm1.1Jcar
Ntrk1tm1Apat/Ntrk1tm1Apat
Ntrk1tm1Bbd/Ntrk1tm1Bbd
Ntrk1tm1Par/Ntrk1tm1Par
Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Ntrk1tm2.1Tes/Ntrk1tm2.1Tes *
Ntrk1tm2.1Lfr/Ntrk1tm2.1Lfr
Tg(dlx5a-cre)1Mekk/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory