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Symbol
Name
ID
Notch1
notch 1
MGI:97363
Phenotype annotations related to vision/eye
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Cataract
Developmental cataract
Optic atrophy
Hypertelorism
Microphthalmia
Strabismus
Esotropia
Disease(s) Associated with NOTCH1
Adams-Oliver syndrome

Mouse Phenotypes
vision/eye phenotype
abnormal retinal blood vessel morphology
corneal vascularization
Meibomian gland degeneration
lacrimal gland degeneration
decreased conjunctiva goblet cell number
abnormal cornea morphology
corneal deposits
dry eyes
Availability Mouse Genotype
Notch1tm1Grid/Notch1+
Notch1tm2Rko/Notch1tm2Rko
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-cre)1Jaw/0  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+  (conditional)
*
Notch1tm2Rko/Notch1tm3(cre)Rko  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory