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Symbol
Name
ID
Notch1
notch 1
MGI:97363
Phenotype annotations related to liver/biliary system
Darker colors indicate more annotations
Human Phenotypes
Portal hypertension
Cirrhosis
Congenital hepatic fibrosis
Disease(s) Associated with NOTCH1
Adams-Oliver syndrome

Mouse Phenotypes
enlarged liver sinusoidal spaces
liver inflammation
abnormal liver morphology
abnormal hepatic cord morphology
abnormal liver parenchyma morphology
abnormal liver lobule morphology
increased liver weight
hepatic steatosis
pale liver
increased cholangiocarcinoma incidence
Availability Mouse Genotype
Albtm1(cre/ERT2)Mtz/Alb+
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Adipoq-cre)1Evdr/0  (conditional)
Notch1tm2Rko/Notch1tm3(cre)Rko  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory