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Symbol
Name
ID
Notch1
notch 1
MGI:97363
Phenotype annotations related to immune system
Darker colors indicate more annotations
Human Phenotypes
Leukopenia
Splenomegaly
Hypersplenism
Disease(s) Associated with NOTCH1
Adams-Oliver syndrome

Mouse Phenotypes
increased T cell apoptosis
abnormal thymus morphology
abnormal thymus cell ratio
small thymus
thymus hypoplasia
decreased thymocyte number
abnormal B cell differentiation
increased immature B cell number
abnormal T cell differentiation
abnormal CD8-positive, alpha-beta T cell differentiation
abnormal T cell receptor beta chain V(D)J recombination
decreased double-negative T cell number
decreased double-positive T cell number
decreased B cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta T cell number
decreased T cell number
decreased single-positive T cell number
increased single-positive T cell number
increased leukocyte cell number
abnormal B cell morphology
abnormal spleen morphology
enlarged spleen
liver inflammation
Availability Mouse Genotype
Notch1tm2Pst/Notch1tm2Pst
Tg(LckNotch1)9Erob/?
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0  (conditional)
Cpa3tm3(icre)Hrr/Cpa3+
Notch1tm1Agt/Notch1tm1Agt  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0  (conditional)
Notch1tm2Rko/Notch1tm3(cre)Rko  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory