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Symbol
Name
ID
Notch1
notch 1
MGI:97363
Phenotype annotations related to endocrine/exocrine glands
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
abnormal exocrine pancreas morphology
abnormal pancreatic duct morphology
endocrine/exocrine gland phenotype
abnormal endocrine pancreas morphology
abnormal pancreatic islet morphology
decreased pancreatic alpha cell number
absent pancreatic alpha cells
decreased pancreatic beta cell number
absent pancreatic islets
abnormal thymus morphology
abnormal thymus cell ratio
small thymus
thymus hypoplasia
decreased thymocyte number
Meibomian gland degeneration
small sebaceous gland
lacrimal gland degeneration
abnormal pancreas morphology
abnormal pancreas development
increased T cell derived lymphoma incidence
Availability Mouse Genotype
Notch1tm2Pst/Notch1tm2Pst
Tg(LckNotch1)9Erob/?
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0  (conditional)
Cpa3tm3(icre)Hrr/Cpa3+
Notch1tm1Agt/Notch1tm1Agt  (conditional)
Notch1tm2Rko/Notch1tm2Rko
Tg(Msx2-cre)5Rem/0  (conditional)
Notch1tm2Rko/Notch1tm2Rko
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-cre)1Jaw/0  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/Esr1*)1Dam/0  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1(cre/ERT2)Lcm/Hes1+  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre)C1Able/0  (conditional)
*
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurod1-cre)1Able/0  (conditional)
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/ERT2)1Able/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory