Symbol
Name
ID

Nos1
nitric oxide synthase 1, neuronal
MGI:97360

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Depression	Apathy	Reduced social reciprocity	Impulsivity	Agitation	Restless legs
Disease(s) Associated with NOS1	Depression	Apathy	Reduced social reciprocity	Impulsivity	Agitation	Restless legs
cystic fibrosis
Parkinson's disease

Mouse Phenotypes

behavior/neurological phenotype

increased alcohol consumption

abnormal behavioral response to addictive substance

enhanced behavioral response to addictive substance

abnormal spatial learning

abnormal liquid preference

decreased aggression towards male mice

increased aggression towards female mice

increased aggression towards male mice

increased coping response

increased anxiety-related response

increased grooming behavior

enhanced coordination

impaired balance

abnormal sleep pattern

abnormal maternal behavior

abnormal mating frequency

abnormal seizure response to inducing agent

Availability

Mouse Genotype

Nos1^tm1Plh/Nos1^tm1Plh

Nos1^tm2Plh/Nos1^tm2Plh

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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