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Symbol Name ID |
Nodal
nodal growth differentiation factor MGI:97359 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Polyhydramnios |
| Disease(s) Associated with NODAL | |
| visceral heterotaxy |
| Mouse Phenotypes | embryo phenotype |
abnormal developmental patterning |
abnormal gastrulation |
abnormal embryo turning |
abnormal gastrulation movements |
abnormal germ layer development |
abnormal ectoderm development |
abnormal mesendoderm development |
abnormal mesoderm development |
abnormal left-right axis patterning |
abnormal proximal-distal axis patterning |
abnormal rostral-caudal axis patterning |
rostral body truncation |
embryonic growth arrest |
decreased embryo size |
abnormal embryonic tissue morphology |
abnormal lateral plate mesoderm morphology |
absent mesoderm |
absent head fold |
abnormal neural fold formation |
abnormal embryonic neuroepithelium morphology |
absent floor plate |
absent notochord |
truncated notochord |
abnormal prechordal plate morphology |
absent prechordal plate |
abnormal primitive streak morphology |
abnormal primitive node morphology |
absent primitive node |
failure of primitive streak formation |
fused somites |
absent somites |
embryonic-extraembryonic boundary constriction |
increased trophoblast giant cell number |
small ectoplacental cone |
abnormal extraembryonic tissue morphology |
absent allantois |
absent amnion |
absent amniotic folds |
abnormal extraembryonic ectoderm morphology |
abnormal parietal yolk sac morphology |
abnormal spongiotrophoblast layer morphology |
increased spongiotrophoblast size |
thin placenta labyrinth |
absent placental labyrinth |
abnormal visceral yolk sac morphology |
absent visceral yolk sac |
abnormal extraembryonic mesoderm development |
abnormal visceral endoderm morphology |
abnormal anterior visceral endoderm morphology |
abnormal distal visceral endoderm morphology |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||
| NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nodaltm1Hmd/Nodaltm1Hmd | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nodaltm1Rob/Nodaltm1Rob | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nodaltm2Rob/Nodaltm2Rob | * | |||||||||||||||||||||||||||||||||||||||||||||||||||
| NodalTgR(MPSVNeo)413.dRob/Nodaltm1Mku | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nodaltm1Mku/Nodaltm1.1Mku | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nodaltm1Rob/Nodaltm2Rob | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nodaltm1Rob/Nodaltm5Rob Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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| Meox2tm1(cre)Sor/Meox2+ Nodaltm1Rob/Nodaltm5Rob (conditional) |
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| Nodaltm1.1Mku/Nodaltm2Mku Tg(T-cre)1Lwd/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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