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Symbol
Name
ID
Nkx2-5
NK2 homeobox 5
MGI:97350
Phenotype annotations related to muscle
Darker colors indicate more annotations
Human Phenotypes
Macroglossia
Muscular hypotonia
Disease(s) Associated with NKX2-5
congenital nongoitrous hypothyroidism 5

Mouse Phenotypes
abnormal impulse conducting system morphology
abnormal Purkinje fiber morphology
abnormal atrioventricular bundle morphology
abnormal left posterior bundle morphology
abnormal atrioventricular node morphology
atrioventricular node hypoplasia
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
abnormal myocardial trabeculae morphology
abnormal trabecula carnea morphology
absent trabeculae carneae
absent myocardial trabeculae
disorganized myocardium
thin myocardium
dilated cardiomyopathy
decreased ventricle muscle contractility
cardiomyopathy
abnormal myogenesis
Availability Mouse Genotype
Nkx2-5em1Dsr/Nkx2-5em1Dsr
Nkx2-5tm1.1Burg/Nkx2-5tm1.1Burg
Nkx2-5tm1Siz/Nkx2-5tm1Siz
Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Nkx2-5tm2Siz/Nkx2-5tm2Siz
Nkx2-5tm4Rph/Nkx2-5tm4Rph
Nkx2-5tm1.1Hkas/Nkx2-5+
Nkx2-5tm1Siz/Nkx2-5+
Nkx2-5tm2.1Mwc/Nkx2-5+
Nkx2-5tm2Siz/Nkx2-5+
Nkx2-5tm3.1Mwc/Nkx2-5+
Nkx2-5tm4Rph/Nkx2-5+
Myl2tm1(cre)Krc/Myl2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc  (conditional)
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Tmj/Isl1+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory