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nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased B cell proliferation
increased B cell proliferation
decreased T cell proliferation
increased susceptibility to induced colitis
large intestinal inflammation
cecum inflammation
peritoneal inflammation
abnormal class switch recombination
myeloid hyperplasia
decreased myeloid dendritic cell number
decreased B-1 B cell number
decreased B-1a cell number
decreased marginal zone B cell number
decreased NK cell number
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
decreased central memory CD4-positive, alpha-beta T cell number
decreased effector memory CD4-positive, alpha-beta T cell number
increased CD4-positive, alpha beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased NK T cell number
decreased memory T cell number
decreased regulatory T cell number
decreased single-positive T cell number
increased T cell number
decreased osteoclast cell number
increased leukocyte cell number
enlarged spleen
abnormal lymphocyte physiology
abnormal B cell physiology
decreased IgA level
decreased IgE level
increased IgE level
decreased IgG1 level
increased IgG1 level
decreased IgG3 level
decreased IgG level
decreased IgM level
decreased immunoglobulin level
increased immunoglobulin level
abnormal CD4-positive, alpha-beta T cell physiology
abnormal macrophage physiology
decreased circulating interleukin-2 level
abnormal Peyer's patch follicle morphology
abnormal Peyer's patch T cell area morphology
abnormal Peyer's patch germinal center morphology
decreased Peyer's patch number
small Peyer's patches
enlarged lymph nodes
abnormal inguinal lymph node morphology
absent inguinal lymph nodes
small inguinal lymph nodes
abnormal lymph organ size
lymphoid hyperplasia
abnormal professional antigen presenting cell physiology
abnormal dendritic cell physiology
abnormal humoral immune response
impaired humoral immune response
abnormal cytokine secretion
decreased interleukin-1 beta secretion
decreased interleukin-2 secretion
decreased interleukin-4 secretion
decreased interleukin-6 secretion
decreased tumor necrosis factor secretion
decreased susceptibility to autoimmune diabetes
abnormal inflammatory response
liver inflammation
lung inflammation
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
decreased susceptibility to viral infection induced morbidity/mortality
Availability Mouse Genotype
Nfkb1tm1Bal/Nfkb1tm1Bal *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory