|
Symbol Name ID |
Nf1
neurofibromin 1 MGI:97306 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukemia |
Acute myeloid leukemia |
Chronic myelogenous leukemia |
Juvenile myelomonocytic leukemia |
Lisch nodules |
Neoplasm of the breast |
Neoplasm of the gastrointestinal tract |
Gastrointestinal stroma tumor |
Parathyroid adenoma |
Carcinoid tumor |
Pheochromocytoma |
Urinary tract neoplasm |
Neoplasm of the skin |
Neurofibroma |
Spinal neurofibroma |
Symmetric spinal nerve root neurofibromas |
Plexiform neurofibroma |
Multiple lipomas |
Rhabdomyosarcoma |
Astrocytoma |
Optic nerve glioma |
Meningioma |
Neuroblastoma |
Neoplasm |
Sarcoma |
Neurofibrosarcoma |
| Disease(s) Associated with NF1 | ||||||||||||||||||||||||||
| acute myeloid leukemia | ||||||||||||||||||||||||||
| juvenile myelomonocytic leukemia | ||||||||||||||||||||||||||
| neurofibromatosis 1 | ||||||||||||||||||||||||||
| neurofibromatosis-Noonan syndrome | ||||||||||||||||||||||||||
| spinal neurofibromatosis | ||||||||||||||||||||||||||
| Watson syndrome |
| Mouse Phenotypes | neoplasm |
increased adrenal gland tumor incidence |
increased pheochromocytoma incidence |
increased hepatoma incidence |
increased neurofibroma incidence |
increased leukemia incidence |
increased lymphoma incidence |
increased lung adenocarcinoma incidence |
increased fibrosarcoma incidence |
increased neurofibrosarcoma incidence |
increased ganglioneuroma incidence |
increased gangliosarcoma incidence |
increased glioma incidence |
increased tumor incidence |
|
| Availability | Mouse Genotype | ||||||||||||||
| Nf1tm1Cbr/Nf1tm1Cbr | * | ||||||||||||||
| Nf1tm1Cbr/Nf1+ | * | ||||||||||||||
| Nf1tm1Tyj/Nf1+ | |||||||||||||||
| Nf1tm1Tyj/Nf1tm2Tyj | |||||||||||||||
| Nf1tm1c(KOMP)Wtsi/Nf1tm1c(KOMP)Wtsi Tg(Dhh-cre)1Mejr/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Par Tg(Syn1-cre)671Jxm/0 (conditional) |
* | ||||||||||||||
| Nf1tm1Par/Nf1tm1Par Tg(Mpz-cre)94Imeg/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Par Tg(Pax3-cre)1Joe/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Par H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Nf1tm1Par/Nf1tm1Par Tg(Gfap-cre)77.6Mvs/0 (conditional) |
* | ||||||||||||||
| Nf1tm1.1Kest/Nf1tm1c(KOMP)Wtsi Tg(Dhh-cre)1Mejr/0 (conditional) |
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| Nf1tm1Fcr/Nf1+ Tg(GFAP-cre)#Gtm/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Fcr Tg(GFAP-cre)#Gtm/0 (conditional) |
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| Nf1tm1Par/Nf1tm1Tyj Tg(Postn-cre)1Sjc/0 (conditional) |
* | ||||||||||||||
| Nf1tm1Par/Nf1tm1Tyj Tg(Mpz-cre)1Brn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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