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Symbol
Name
ID
Nf1
neurofibromin 1
MGI:97306
Phenotype annotations related to muscle
Darker colors indicate more annotations
Human Phenotypes
Lower limb muscle weakness
Muscle weakness
Abdominal wall muscle weakness
Rhabdomyosarcoma
Disease(s) Associated with NF1
neurofibromatosis 1
neurofibromatosis-Noonan syndrome
spinal neurofibromatosis

Mouse Phenotypes
abnormal myocardium layer morphology
thin myocardium compact layer
disorganized myocardium
thin myocardium
abnormal myoblast differentiation
increased myoblast proliferation
abnormal muscle morphology
abnormal muscle development
abnormal myogenesis
delayed muscle development
abnormal muscle fiber morphology
decreased skeletal muscle fiber number
decreased muscle weight
skeletal muscle hypoplasia
decreased skeletal muscle mass
skeletal muscle fibrosis
abnormal muscle physiology
Availability Mouse Genotype
Nf1tm1Fcr/Nf1tm1Fcr
Nf1tm1Tyj/Nf1tm1Tyj
Nf1tm1Tyj/Nf1tm2Tyj
Nf1tm1Par/Nf1tm1Par
Tg(Tek-cre)1Ywa/0  (conditional)
Nf1tm1Par/Nf1tm1Par
Tg(Prrx1-cre)1Cjt/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory