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Symbol
Name
ID
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
MGI:97255
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Prolonged QT interval
Aortic regurgitation
Arrhythmia
Sick sinus syndrome
Sinus bradycardia
Cardiac arrest
Atrial fibrillation
Ventricular escape rhythm
Ventricular fibrillation
Atrioventricular block
Congestive heart failure
Secundum atrial septal defect
Subvalvular aortic stenosis
Left ventricular hypertrophy
Mitral valve prolapse
Left ventricular noncompaction
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Asymmetric septal hypertrophy
Disease(s) Associated with MYH6
atrial heart septal defect 3
dilated cardiomyopathy 1EE
hypertrophic cardiomyopathy 1
hypertrophic cardiomyopathy 14
sick sinus syndrome

Mouse Phenotypes
cardiovascular system phenotype
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
enlarged myocardial fiber
calcified myocardium
disorganized myocardium
myocardium hypertrophy
myocardium necrosis
heart left ventricle hypertrophy
abnormal heart morphology
abnormal heart atrium morphology
dilated heart atrium
enlarged heart atrium
increased heart weight
cardiac hypertrophy
abnormal heart ventricle morphology
abnormal heart left ventricle morphology
dilated heart left ventricle
thick ventricular wall
thin ventricular wall
cardiac fibrosis
cardiac interstitial fibrosis
dilated cardiomyopathy
dystrophic cardiac calcinosis
abnormal cardiovascular system physiology
decreased cardiac output
decreased cardiac stroke volume
decreased cardiac muscle contractility
decreased ventricle muscle contractility
increased cardiac muscle contractility
abnormal cardiac muscle relaxation
abnormal heart echocardiography feature
abnormal heart ventricle pressure
decreased left ventricle diastolic pressure
decreased left ventricle systolic pressure
irregular heartbeat
abnormal myocardial fiber physiology
increased cardiomyocyte apoptosis
cardiomyopathy
Availability Mouse Genotype
Myh6tm1.1Jpsc/Myh6tm1.1Jpsc *
Myh6tm1Ces/Myh6tm1Ces
Myh6tm1Jse/Myh6tm1Jse
Myh6tm2Ces/Myh6tm2Ces
Myh6tm2Jse/Myh6tm2Jse
Myh6tm3.1Jse/Myh6tm3.1Jse
Myh6tm1.1Jpsc/Myh6+ *
Myh6tm1.1Jpsc/Myh6tm2Jse
Myh6tm1Ces/Myh6+
Myh6tm1Jse/Myh6+
Myh6tm1Rbns/Myh6+
Myh6tm2Ces/Myh6+
Myh6tm2Jse/Myh6+
Myh6tm3.1Jse/Myh6+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory