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Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hyposmia
Blepharospasm
Eyelid apraxia
Retrocollis
Orthostatic hypotension due to autonomic dysfunction
Dysphagia
Photophobia
Frequent falls
Amyotrophic lateral sclerosis
Substantia nigra gliosis
Neuronal loss in basal ganglia
Cerebral cortical atrophy
Lewy bodies
Neurofibrillary tangles
Granulovacuolar degeneration
Gliosis
Neuronal loss in central nervous system
Abnormal synaptic transmission
Bradykinesia
Parkinsonism
Parkinsonism with favorable response to dopaminergic medication
Rigidity
Cognitive impairment
Memory impairment
Mental deterioration
Dementia
Frontal lobe dementia
Frontolimbic dementia
Frontotemporal dementia
Language impairment
Micrographia
Aphasia
Dysarthria
Echolalia
Mutism
Primitive reflex
Akinesia
Dyskinesia
Dystonia
Axial dystonia
Limb dystonia
Frontal release signs
Falls
Gait imbalance
Shuffling gait
Short stepped shuffling gait
Unsteady gait
Stereotypy
Tremor
Postural tremor
Resting tremor
Postural instability
Polyphagia
Diminished motivation
Apathy
Emotional blunting
Irritability
Hallucinations
Visual hallucinations
Hyperorality
Depressivity
Disinhibition
Impulsivity
Inappropriate laughter
Inappropriate sexual behavior
Low frustration tolerance
Perseveration
Personality changes
Agitation
Schizophrenia
Sleep disturbance
Delayed speech and language development
Pseudobulbar signs
Abnormal autonomic nervous system physiology
Disease(s) Associated with MAPT
frontotemporal dementia
late onset Parkinson's disease
Pick's disease
progressive supranuclear palsy

Mouse Phenotypes
nervous system phenotype
decreased susceptibility to pharmacologically induced seizures
abnormal axon extension
decreased muscle spindle number
abnormal hippocampus CA1 region morphology
abnormal dentate gyrus morphology
abnormal hippocampus pyramidal cell morphology
enlarged hippocampus
abnormal motor neuron innervation pattern
abnormal sensory neuron innervation pattern
abnormal axon morphology
abnormal synaptic bouton morphology
abnormal dendrite morphology
abnormal sensory neuron morphology
abnormal dorsal root ganglion morphology
abnormal axonal transport
abnormal excitatory postsynaptic potential
reduced long term potentiation
Availability Mouse Genotype
Kansl1/Mapttm1.1Cole/Kansl1/Mapttm1.1Cole *
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln *
Mapttm1Aha/Mapttm1Aha
Mapttm1Hnd/Mapttm1Hnd
Mapttm1Noh/Mapttm1Noh
Mapttm2(cre)Aha/Mapttm2(cre)Aha *
Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Mapttm1Hnd/Mapt+
Chattm2(cre)Lowl/Chat+
Mapttm3(Sema3e)Arbr/Mapttm3(Sema3e)Arbr  (conditional)
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+  (conditional)
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+  (conditional)
Mapttm1(Sema3e)Yuyo/Mapt+
Olig2tm1(cre)Tmj/Olig2+  (conditional)
*
Mapttm2Arbr/Mapt+
Pvalbtm1(cre)Arbr/Pvalb+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory