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Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Photophobia
Echolalia
Mutism
Polyphagia
Diminished motivation
Apathy
Emotional blunting
Irritability
Hallucinations
Visual hallucinations
Hyperorality
Depressivity
Disinhibition
Impulsivity
Inappropriate laughter
Inappropriate sexual behavior
Low frustration tolerance
Perseveration
Personality changes
Agitation
Schizophrenia
Sleep disturbance
Monotonic speech
Weak voice
Disease(s) Associated with MAPT
frontotemporal dementia
late onset Parkinson's disease
Pick's disease
progressive supranuclear palsy

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
decreased susceptibility to pharmacologically induced seizures
impaired contextual conditioning behavior
impaired cued conditioning behavior
abnormal motor learning
abnormal long term object recognition memory
abnormal spatial learning
enhanced spatial learning
abnormal spatial working memory
decreased anxiety-related response
abnormal motor coordination/balance
decreased grip strength
hyperactivity
Availability Mouse Genotype
Kansl1/Mapttm1.1Cole/Kansl1/Mapttm1.1Cole *
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt *
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba *
Mapttm1.1Cole/Mapttm1.1Cole *
Mapttm1b(EUCOMM)Hmgu/Mapttm1b(EUCOMM)Hmgu
Mapttm1Hnd/Mapttm1Hnd
Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Mapttm1Hnd/Mapt+
Chattm2(cre)Lowl/Chat+
Mapttm3(Sema3e)Arbr/Mapttm3(Sema3e)Arbr  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory