Symbol
Name
ID

Tlr4
toll-like receptor 4
MGI:96824

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Pedal edema

Abnormality of metabolism/homeostasis

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating C-reactive protein concentration

Elevated circulating amyloid A concentration

Elevated erythrocyte sedimentation rate

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Insulin resistance

Pleural effusion

Fever

Recurrent fever

Food intolerance

Hematuria

Decreased level of D-mannose in urine

Proteinuria

Amyloidosis

Renal amyloidosis

Ascites

Disease(s) Associated with TLR4

atopic dermatitis

Behcet's disease

coronary artery disease

familial mediterranean fever

temporal arteritis

type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased response of heart to induced stress

abnormal vascular wound healing

abnormal circulating glucose level

decreased circulating insulin level

abnormal circulating leptin level

decreased circulating interleukin-6 level

increased circulating interleukin-6 level

abnormal circulating enzyme level

decreased circulating alanine transaminase level

decreased body temperature

pulmonary edema

abnormal gas homeostasis

increased oxygen consumption

decreased respiratory quotient

abnormal glucose homeostasis

improved glucose tolerance

increased adiponectin level

abnormal bile salt level

abnormal lipid level

abnormal fatty acids level

decreased liver triglyceride level

abnormal cytokine level

abnormal interleukin level

abnormal tumor necrosis factor level

decreased incidence of tumors by chemical induction

decreased susceptibility to ischemic brain injury

decreased cerebral infarct size

decreased susceptibility to kidney reperfusion injury

decreased susceptibility to injury

Availability

Mouse Genotype

Tlr4^Lps-d/Tlr4^Lps-d

Tlr4^lps-del/Tlr4^lps-del

Tlr4^tm1.1Djh/Tlr4^tm1.1Djh

Tlr4^tm1Aki/Tlr4^tm1Aki

Tlr4^tm1Djh/Tlr4^tm1Djh
Tg(Vil1-cre)997Gum/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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