Symbol
Name
ID

Lpl
lipoprotein lipase
MGI:96820

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Increased circulating chylomicron concentration

Increased LDL cholesterol concentration

Increased VLDL cholesterol concentration

Hypercholesterolemia

Hyperlipidemia

Hypertriglyceridemia

Lactescent serum

Elevated circulating apolipoprotein A-II concentration

Elevated circulating apolipoprotein B concentration

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Insulin resistance

Disease(s) Associated with LPL

coronary artery disease

familial combined hyperlipidemia

familial lipoprotein lipase deficiency

type 2 diabetes mellitus

Mouse Phenotypes

decreased cardiac muscle triglyceride level

decreased circulating HDL cholesterol level

increased circulating HDL cholesterol level

decreased circulating LDL cholesterol level

increased circulating VLDL cholesterol level

increased circulating cholesterol level

increased circulating phospholipid level

increased circulating triglyceride level

increased circulating VLDL triglyceride level

hyperlipidemia

cyanosis

abnormal glucose homeostasis

abnormal lipid homeostasis

increased cholesterol level

abnormal lipid level

decreased fatty acids level

increased triglyceride level

Availability

Mouse Genotype

Lpl^tm1Bres/Lpl^tm1Bres

Lpl^tm1Sem/Lpl^tm1Sem

Lpl^tm1Bres/Lpl⁺

Lpl^tm1Sem/Lpl⁺

Lpl^tm1Ijg/Lpl^tm1Ijg
Tg(Myh6-cre)2182Mds/? (conditional)

Lpl^tm1Ijg/Lpl^tm1Ijg
Tg(Myh6-cre)2182Mds/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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