Symbol
Name
ID

Lmna
lamin A
MGI:96794

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal lymphocyte physiology

Decreased HDL cholesterol concentration

Increased LDL cholesterol concentration

Hypercholesterolemia

Hyperlipidemia

Hypertriglyceridemia

Elevated circulating creatine kinase concentration

Mildly elevated creatine kinase

Elevated circulating alanine aminotransferase concentration

Elevated circulating aspartate aminotransferase concentration

Hyperglycemia

Diabetes mellitus

Insulin-resistant diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Hyperinsulinemia

Insulin resistance

Hepatic steatosis

Aortic valve calcification

Mitral valve calcification

Decreased serum leptin

Subcutaneous calcification

Chondrocalcinosis

Ectopic calcification

Disease(s) Associated with LMNA

autosomal dominant Emery-Dreifuss muscular dystrophy 2

autosomal recessive Emery-Dreifuss muscular dystrophy 3

congenital muscular dystrophy due to LMNA mutation

dilated cardiomyopathy 1A

Emery-Dreifuss muscular dystrophy

familial partial lipodystrophy type 2

mandibuloacral dysplasia type A lipodystrophy

progeria

type 2 diabetes mellitus

Werner syndrome

Mouse Phenotypes

homeostasis/metabolism phenotype

impaired exercise endurance

abnormal double-strand DNA break repair

abnormal DNA replication

decreased circulating carnitine level

abnormal blood homeostasis

decreased circulating glucose level

hypoglycemia

decreased circulating insulin level

increased circulating insulin level

decreased circulating leptin level

increased circulating growth hormone level

increased circulating ketone body level

decreased circulating lactate level

increased circulating LDL cholesterol level

increased circulating cholesterol level

decreased circulating triglyceride level

increased circulating phosphate level

increased circulating alanine transaminase level

increased circulating alkaline phosphatase level

increased circulating aspartate transaminase level

increased circulating creatine kinase level

decreased core body temperature

pulmonary edema

impaired glucose tolerance

improved glucose tolerance

decreased liver glycogen level

insulin resistance

increased circulating adiponectin level

increased liver triglyceride level

increased triglyceride level

abnormal urine homeostasis

enhanced exercise endurance

Availability

Mouse Genotype

Lmna^{Gt(S7-1F1)Sor}/Lmna^{Gt(S7-1F1)Sor}

Lmna^tm1.1Otin/Lmna^tm1.1Otin

Lmna^tm1.1Vde/Lmna^tm1.1Vde

Lmna^tm1Gbon/Lmna^tm1Gbon

Lmna^tm1Rben/Lmna^tm1Rben

Lmna^tm1Stw/Lmna^tm1Stw

Lmna^tm2.1Gbon/Lmna^tm2.1Gbon

Lmna^Dhe/Lmna⁺

Lmna^em1Fenz/Lmna⁺

Lmna^tm1.1Otin/Lmna⁺

Lmna^{tm1b(EUCOMM)Wtsi}/Lmna⁺

Lmna^tm1Stw/Lmna⁺

Lmna^tm2.1Gbon/Lmna⁺

Lmna^tm1Bliu/Lmna⁺
Tg(Tek-cre)1Ywa/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23