|
Symbol Name ID |
Lmna
lamin A MGI:96794 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased adipose tissue around the neck |
Neck joint contracture |
Splenomegaly |
Hepatomegaly |
Prominent umbilicus |
Delayed menarche |
Short stature |
Slender build |
Increased waist to hip ratio |
Failure to thrive |
Severe failure to thrive |
Weight loss |
Cachexia |
Obesity |
Growth delay |
Intrauterine growth retardation |
Postnatal growth retardation |
| Disease(s) Associated with LMNA | |||||||||||||||||
| autosomal dominant Emery-Dreifuss muscular dystrophy 2 | |||||||||||||||||
| congenital muscular dystrophy due to LMNA mutation | |||||||||||||||||
| Emery-Dreifuss muscular dystrophy | |||||||||||||||||
| familial partial lipodystrophy type 2 | |||||||||||||||||
| mandibuloacral dysplasia type A lipodystrophy | |||||||||||||||||
| progeria | |||||||||||||||||
| restrictive dermopathy 2 | |||||||||||||||||
| type 2 diabetes mellitus | |||||||||||||||||
| Werner syndrome |
| Mouse Phenotypes | enlarged heart |
cardiac hypertrophy |
abnormal incisor morphology |
small lower incisors |
short upper incisors |
malocclusion |
abnormal hard palate morphology |
abnormal tongue morphology |
short snout |
prominent ears |
short ears |
meteorism |
growth/size/body region phenotype |
decreased body weight |
slow postnatal weight gain |
weight loss |
increased body weight |
decreased body height |
decreased body size |
postnatal growth retardation |
|
| Availability | Mouse Genotype | ||||||||||||||||||||
| LmnaDhe/LmnaDhe | |||||||||||||||||||||
| LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor | |||||||||||||||||||||
| Lmnatm1.1Bliu/Lmnatm1.1Bliu | |||||||||||||||||||||
| Lmnatm1.1Otin/Lmnatm1.1Otin | |||||||||||||||||||||
| Lmnatm1.2Yxz/Lmnatm1.2Yxz | |||||||||||||||||||||
| Lmnatm1Gbon/Lmnatm1Gbon | |||||||||||||||||||||
| Lmnatm1Lgf/Lmnatm1Lgf | |||||||||||||||||||||
| Lmnatm1Stw/Lmnatm1Stw | |||||||||||||||||||||
| Lmnatm2.1Gbon/Lmnatm2.1Gbon | |||||||||||||||||||||
| Lmnatm2Stw/Lmnatm2Stw | |||||||||||||||||||||
| Lmnatm3Lgf/Lmnatm3Lgf | |||||||||||||||||||||
| Lmnatm3Stw/Lmnatm3Stw | |||||||||||||||||||||
| Lmnatm5Lgf/Lmnatm5Lgf | |||||||||||||||||||||
| Lmnatm6Lgf/Lmnatm6Lgf | |||||||||||||||||||||
| Lmnatm8Lgf/Lmnatm8Lgf | * | ||||||||||||||||||||
| Lmnatm11Lgf/Lmnatm11Lgf | |||||||||||||||||||||
| LmnaDhe/Lmna+ | |||||||||||||||||||||
| Lmnaem1Fenz/Lmna+ | |||||||||||||||||||||
| Lmnatm1.1Bliu/Lmna+ | |||||||||||||||||||||
| Lmnatm1.1Otin/Lmna+ | |||||||||||||||||||||
| Lmnatm1Lgf/Lmna+ | |||||||||||||||||||||
| Lmnatm2.1Gbon/Lmna+ | |||||||||||||||||||||
| Lmnatm3Lgf/Lmna+ | |||||||||||||||||||||
| Lmnatm4Lgf/Lmna+ | |||||||||||||||||||||
| Lmnatm11Lgf/Lmna+ | |||||||||||||||||||||
| Lmnatm4Stw/Lmnatm4Stw Tg(Zp3-cre)93Knw/0 (conditional) |
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| Lmnatm1Bliu/Lmna+ Tg(Tek-cre)1Ywa/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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