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Symbol
Name
ID

Lmna
lamin A
MGI:96794

Phenotype annotations related to craniofacial

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Alopecia of scalp

Sparse scalp hair

Micrognathia

Microretrognathia

Retrognathia

Malar flattening

Hypoplastic facial bones

Shallow orbits

Relative macrocephaly

Delayed cranial suture closure

Wormian bones

Large fontanelles

Bird-like facies

Craniofacial disproportion

Round face

Narrow face

Full cheeks

Midface retrusion

Increased facial adipose tissue

Short chin

Thin vermilion border

Ankyloglossia

Short lingual frenulum

High palate

Narrow mouth

Abnormality of the dentition

Hypodontia

Advanced eruption of teeth

Delayed eruption of teeth

Impacted tooth

Persistence of primary teeth

Hypoplasia of teeth

Premature loss of teeth

Dental crowding

Neoplasm of the oral cavity

Convex nasal ridge

Narrow nasal ridge

Abnormal nasal tip morphology

Narrow nasal tip

Wide nasal bridge

Narrow nose

Abnormal eyebrow morphology

Absent eyebrow

Loss of eyelashes

Absent eyelashes

Nocturnal lagophthalmos

Disease(s) Associated with LMNA

dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome

familial partial lipodystrophy type 2

mandibuloacral dysplasia type A lipodystrophy

progeria

restrictive dermopathy 2

Werner syndrome

Mouse Phenotypes

craniofacial phenotype

abnormal cranial suture morphology

abnormal coronal suture morphology

abnormal lambdoid suture morphology

abnormal sagittal suture morphology

wide cranial sutures

abnormal frontonasal suture morphology

abnormal cranium morphology

abnormal cranium size

decreased cranium height

decreased cranium width

small cranium

abnormal neurocranium morphology

abnormal zygomatic arch morphology

shallow orbits

abnormal incisor morphology

small lower incisors

short upper incisors

malocclusion

mandible hypoplasia

short maxilla

micrognathia

abnormal hard palate morphology

abnormal tongue morphology

short snout

prominent ears

short ears

Availability

Mouse Genotype

Lmna^Dhe/Lmna^Dhe

Lmna^{Gt(S7-1F1)Sor}/Lmna^{Gt(S7-1F1)Sor}

*

Lmna^tm1.1Otin/Lmna^tm1.1Otin

Lmna^tm1Lgf/Lmna^tm1Lgf

Lmna^tm2Stw/Lmna^tm2Stw

Lmna^Dhe/Lmna⁺

Lmna^tm1Lgf/Lmna⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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