Symbol
Name
ID

Lipa
lysosomal acid lipase A
MGI:96789

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Hyperkalemia

Hyponatremia

Decreased HDL cholesterol concentration

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating hepatic transaminase concentration

Elevated circulating alanine aminotransferase concentration

Elevated circulating aspartate aminotransferase concentration

Increased circulating lactate dehydrogenase concentration

Elevated gamma-glutamyltransferase level

Elevated circulating alkaline phosphatase concentration

Low alkaline phosphatase

Reduced lysosomal acid lipase activity

Acidosis

Dehydration

Fever

Hepatic steatosis

Microvesicular hepatic steatosis

Abnormal urine potassium concentration

Hypernatriuria

Renal salt wasting

Ascites

Adrenal calcification

Disease(s) Associated with LIPA

cholesterol ester storage disease

lysosomal acid lipase deficiency

Wolman disease

Mouse Phenotypes

abnormal lipid oxidation

decreased susceptibility to diet-induced obesity

increased circulating insulin level

increased circulating ketone body level

decreased circulating HDL cholesterol level

increased circulating LDL cholesterol level

increased circulating cholesterol level

increased circulating free fatty acids level

increased circulating alanine transaminase level

increased circulating aspartate transaminase level

increased respiratory quotient

impaired gluconeogenesis

improved glucose tolerance

increased insulin sensitivity

insulin resistance

increased liver cholesterol level

abnormal lipid level

decreased unsaturated fatty acids level

increased unsaturated fatty acids level

decreased liver triglyceride level

increased liver triglyceride level

abnormal carbohydrate metabolism

abnormal enzyme/coenzyme activity

decreased triglyceride lipase activity

Availability

Mouse Genotype

Lipa^tm1Ggb/Lipa^tm1Ggb

Lipa^{tm1c(EUCOMM)Hmgu}/Lipa^{tm1c(EUCOMM)Hmgu}
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1^{Tg(Alb-cre)21Mgn} (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23