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Symbol
Name
ID
Jup
junction plakoglobin
MGI:96650
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Prolonged QRS complex
T-wave inversion
Arrhythmia
Sudden cardiac death
Palpitations
Ventricular tachycardia
Paroxysmal ventricular tachycardia
Ventricular arrhythmia
Ventricular extrasystoles
Right bundle branch block
Congestive heart failure
Syncope
Abnormal morphology of right ventricular trabeculae
Cardiomyopathy
Dilated cardiomyopathy
Right ventricular cardiomyopathy
Cardiomegaly
Disease(s) Associated with JUP
arrhythmogenic right ventricular dysplasia 12
Naxos disease

Mouse Phenotypes
cardiovascular system phenotype
abnormal cardiovascular system morphology
liver vascular congestion
abnormal myocardial fiber morphology
abnormal intercalated disk morphology
absent cardiac desmosomes
enlarged myocardial fiber
trabecula carnea hypoplasia
calcified myocardium
thin myocardium
cardiac muscle necrosis
heart left ventricle hypertrophy
abnormal heart development
abnormal atrioventricular cushion morphology
abnormal heart morphology
abnormal heart atrium morphology
enlarged heart right atrium
thin interventricular septum
abnormal heart weight
increased heart weight
enlarged heart
abnormal heart ventricle morphology
increased heart left ventricle size
dilated heart left ventricle
abnormal heart right ventricle morphology
increased heart right ventricle size
dilated heart right ventricle
ventricular aneurysm
hemopericardium
cardiac fibrosis
cardiac interstitial fibrosis
dilated heart
abnormal cardiovascular system physiology
abnormal blood circulation
abnormal cardiac muscle contractility
decreased cardiac muscle contractility
decreased ventricle muscle contractility
abnormal heart echocardiography feature
increased heart rate
ventricular tachycardia
irregular heartbeat
abnormal impulse conducting system conduction
prolonged PR interval
atrioventricular block
abnormal heart electrocardiography waveform feature
abnormal P wave
decreased QRS amplitude
increased cardiomyocyte apoptosis
cardiomyopathy
heart inflammation
Availability Mouse Genotype
Juptm1.1Chen/Juptm1.1Chen *
Juptm1Kem/Juptm1Kem
Juptm1Ruiz/Juptm1Ruiz
Juptm1Ruiz/Jup+
Tg(Myh6-Jup*)1Ajm/0
Juptm1Ruiz/Jup+
Tg(Myh6-Jup)2Ajm/0
Tg(Myh6-Jup*)1Ajm/0
Juptm1.1Glr/Juptm1.1Glr
A1cfTg(Myh6-cre/Esr1*)1Jmk/0  (conditional)
*
Juptm1.1Shou/Juptm1.1Shou
Tg(Myh6-cre)2182Mds/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory