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integrin beta 2
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Rectal abscess
Recurrent bacterial infections
Recurrent gram-negative bacterial infections
Recurrent staphylococcal infections
Disease(s) Associated with ITGB2
leukocyte adhesion deficiency 1

Mouse Phenotypes
immune system phenotype
abnormal leukocyte migration
abnormal leukocyte adhesion
abnormal T cell proliferation
decreased T cell proliferation
abnormal NK cell differentiation
abnormal T cell differentiation
myeloid hyperplasia
increased basophil cell number
increased eosinophil cell number
decreased neutrophil cell number
increased neutrophil cell number
increased granulocyte number
abnormal neutrophil morphology
decreased dendritic cell number
increased dendritic cell number
increased B-1b cell number
decreased B cell number
increased B cell number
increased effector memory CD4-positive, alpha-beta T cell number
increased T-helper 1 cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased NK T cell number
decreased single-positive T cell number
increased T cell number
increased lymphocyte cell number
decreased macrophage cell number
increased monocyte cell number
increased leukocyte cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
enlarged spleen
abnormal leukocyte physiology
abnormal neutrophil physiology
impaired neutrophil recruitment
increased IgA level
increased IgE level
decreased IgG level
increased IgG level
increased IgM level
increased immunoglobulin level
impaired natural killer cell mediated cytotoxicity
abnormal T cell physiology
abnormal cytotoxic T cell cytolysis
abnormal T cell activation
increased circulating interleukin-3 level
increased circulating interleukin-6 level
abnormal cytokine level
abnormal immune system cell morphology
enlarged lymph nodes
lymph node hypoplasia
abnormal lymph organ size
decreased susceptibility to type IV hypersensitivity reaction
impaired humoral immune response
increased interferon-beta secretion
decreased interferon-gamma secretion
increased interferon-gamma secretion
decreased acute inflammation
decreased inflammatory response
increased inflammatory response
decreased susceptibility to bacterial infection
increased susceptibility to bacterial infection
Availability Mouse Genotype
Itgb2M1Btlr/Itgb2M1Btlr *
Itgb2tm1Bay/Itgb2tm1Bay ! !
Itgb2tm1Bay/Itgb2tm2Bay !

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory