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Symbol
Name
ID
Itgb2
integrin beta 2
MGI:96611
Phenotype annotations related to hematopoietic system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Leukocytosis
Disease(s) Associated with ITGB2
leukocyte adhesion deficiency 1

Mouse Phenotypes
abnormal leukocyte migration
abnormal leukocyte adhesion
abnormal T cell proliferation
decreased T cell proliferation
abnormal NK cell differentiation
abnormal T cell differentiation
myeloid hyperplasia
increased bone marrow cell number
increased basophil cell number
increased eosinophil cell number
decreased neutrophil cell number
increased neutrophil cell number
increased granulocyte number
abnormal neutrophil morphology
thrombocytosis
decreased dendritic cell number
increased dendritic cell number
increased B-1b cell number
decreased B cell number
increased B cell number
increased effector memory CD4-positive, alpha-beta T cell number
increased T-helper 1 cell number
decreased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased NK T cell number
decreased single-positive T cell number
increased T cell number
increased lymphocyte cell number
decreased macrophage cell number
increased monocyte cell number
increased leukocyte cell number
abnormal spleen morphology
abnormal spleen red pulp morphology
enlarged spleen
abnormal leukocyte physiology
abnormal neutrophil physiology
impaired neutrophil recruitment
increased IgA level
increased IgE level
decreased IgG level
increased IgG level
increased IgM level
increased immunoglobulin level
impaired natural killer cell mediated cytotoxicity
abnormal T cell physiology
abnormal cytotoxic T cell cytolysis
abnormal T cell activation
Availability Mouse Genotype
Itgb2M1Btlr/Itgb2M1Btlr
Itgb2m3Btlr/Itgb2m3Btlr
Itgb2M4Btlr/Itgb2M4Btlr
Itgb2m5Btlr/Itgb2m5Btlr
Itgb2tm1.1Arte/Itgb2tm1.1Arte
Itgb2tm1Bay/Itgb2tm1Bay !
Itgb2tm2Bay/Itgb2tm2Bay

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory