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interferon regulatory factor 1
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
abnormal T cell proliferation
abnormal thymus cell ratio
increased double-positive T cell number
increased B-1 B cell number
decreased NK cell number
abnormal T cell number
increased T-helper 2 cell number
increased CD4-positive, alpha beta T cell number
decreased CD8-positive, alpha-beta T cell number
abnormal T cell morphology
abnormal splenocyte morphology
abnormal lymphocyte physiology
abnormal immunoglobulin level
impaired natural killer cell mediated cytotoxicity
abnormal macrophage physiology
decreased circulating interferon-gamma level
increased circulating interferon-gamma level
abnormal circulating interleukin-10 level
increased circulating interleukin-13 level
decreased circulating interleukin-2 level
increased circulating interleukin-3 level
abnormal circulating interleukin-4 level
increased circulating interleukin-4 level
increased circulating interleukin-5 level
increased circulating interleukin-6 level
abnormal cytokine level
abnormal immune system morphology
abnormal immune system physiology
decreased interferon-alpha secretion
decreased interferon-beta secretion
decreased interferon-gamma secretion
decreased susceptibility to experimental autoimmune encephalomyelitis
decreased susceptibility to induced arthritis
abnormal response to infection
increased susceptibility to viral infection
Availability Mouse Genotype
Irf1M1Btlr/Irf1M1Btlr *
Irf1tm1Mak/Irf1tm1Mak *
Irf1M1Btlr/Irf1+ *

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory