|
Symbol Name ID |
Insr
insulin receptor MGI:96575 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hypokalemia |
Abnormal circulating C-peptide concentration |
Hyperglycemia |
Postprandial hyperglycemia |
Hypoglycemia |
Fasting hypoglycemia |
Hypoglycemic seizures |
Recurrent hypoglycemia |
Recurrent infantile hypoglycemia |
Type II diabetes mellitus |
Hyperinsulinemia |
Fasting hyperinsulinemia |
Hyperinsulinemic hypoglycemia |
Insulin resistance |
Hypercalciuria |
Elevated circulating insulin:C-peptide ratio |
| Disease(s) Associated with INSR | ||||||||||||||||
| Donohue syndrome | ||||||||||||||||
| familial hyperinsulinemic hypoglycemia 5 | ||||||||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
increased cardiac muscle glycogen level |
decreased insulin secretion |
increased insulin secretion |
increased glycosylated hemoglobin level |
decreased circulating glucose level |
increased circulating glucose level |
hyperglycemia |
decreased circulating luteinizing hormone level |
increased circulating insulin level |
increased circulating leptin level |
decreased circulating free fatty acids level |
increased circulating free fatty acids level |
decreased circulating triglyceride level |
increased circulating triglyceride level |
increased circulating alkaline phosphatase level |
increased circulating aspartate transaminase level |
abnormal circulating serum albumin level |
increased oxygen consumption |
abnormal glucose homeostasis |
impaired glucose tolerance |
decreased liver glycogen level |
abnormal insulin clearance |
increased urine glucose level |
increased insulin sensitivity |
insulin resistance |
abnormal lipid homeostasis |
increased bile salt level |
increased fatty acids level |
increased triglyceride level |
ketoacidosis |
ketoaciduria |
abnormal enzyme/coenzyme activity |
decreased susceptibility to xenobiotic induced morbidity/mortality |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||
| InsrM2Btlr/InsrM2Btlr | |||||||||||||||||||||||||||||||||||
| Insrtm1Dac/Insrtm1Dac | |||||||||||||||||||||||||||||||||||
| Insrtm1Jja/Insrtm1Jja | |||||||||||||||||||||||||||||||||||
| Insrtm1Shs/Insrtm1Shs | |||||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm31(H1/tetO-RNAi:Insr)Arte/Gt(ROSA)26Sor+ | |||||||||||||||||||||||||||||||||||
| InsrRgsc294/Insr+ | |||||||||||||||||||||||||||||||||||
| InsrRgsc824/Insr+ | |||||||||||||||||||||||||||||||||||
| InsrRgsc1777/Insr+ | |||||||||||||||||||||||||||||||||||
| Insrtm1Dac/Insr+ | |||||||||||||||||||||||||||||||||||
| Insrtm1Shs/Insr+ | |||||||||||||||||||||||||||||||||||
| Insrtm1Khn/Insrtm1Khn Tg(Ckmm-cre)5Khn/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||
| Insrtm1Khn/Insrtm1Khn Tg(Myhca-cre)1Abel/0 (conditional) |
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| Insrtm1Khn/Insrtm1Khn Tg(Nes-cre)1Kln/0 (conditional) |
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| Insrtm1Khn/Insrtm1Khn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Insrtm1Khn/Insrtm1Khn Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Insrtm1Khn/Insrtm1Khn Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Insrtm1Khn/Insrtm1Khn Tg(Slc2a4-cre)546Dac/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||
| Insrtm1Khn/Insrtm1Khn Tg(Pdgfrb-cre)#Rha/0 (conditional) |
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| Insrtm1Khn/Insrtm1Dac Tg(Ckmm-cre)5Khn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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