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Symbol
Name
ID
Insr
insulin receptor
MGI:96575
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hyperglycemia
Postprandial hyperglycemia
Hyperinsulinemia
Fasting hypoglycemia
Disease(s) Associated with INSR
Donohue syndrome

Mouse Phenotypes
homeostasis/metabolism phenotype
decreased insulin secretion
increased insulin secretion
increased glycosylated hemoglobin level
decreased circulating glucose level
increased circulating glucose level
hyperglycemia
decreased circulating luteinizing hormone level
increased circulating insulin level
increased circulating leptin level
increased circulating ketone body level
decreased circulating free fatty acid level
increased circulating free fatty acid level
decreased circulating triglyceride level
increased circulating triglyceride level
increased circulating alkaline phosphatase level
increased circulating aspartate transaminase level
abnormal circulating serum albumin level
increased oxygen consumption
abnormal glucose homeostasis
impaired glucose tolerance
decreased liver glycogen level
decreased glycogen level
abnormal insulin clearance
increased urine glucose level
increased insulin sensitivity
insulin resistance
abnormal lipid homeostasis
increased bile salt level
increased fatty acid level
increased triglyceride level
ketoaciduria
decreased sensitivity to xenobiotic induced morbidity/mortality
Availability Mouse Genotype
InsrM2Btlr/InsrM2Btlr
Insrtm1Dac/Insrtm1Dac
Insrtm1Jja/Insrtm1Jja
Insrtm1Shs/Insrtm1Shs
InsrRgsc294/Insr+
InsrRgsc824/Insr+
InsrRgsc1777/Insr+
Insrtm1Dac/Insr+
Insrtm1Shs/Insr+
Insrtm1Khn/Insrtm1Khn
Tg(Ckmm-cre)5Khn/0  (conditional)
*
Insrtm1Khn/Insrtm1Khn
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Insrtm1Khn/Insrtm1Khn
Tg(Nes-cre)1Kln/0  (conditional)
Insrtm1Khn/Insrtm1Khn
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tg(Ins2-cre)25Mgn/0  (conditional)
Insrtm1Khn/Insrtm1Khn
Tg(Ins2-cre)25Mgn/0  (conditional)
Insrtm1Khn/Insrtm1Khn
Tg(Slc2a4-cre)546Dac/0  (conditional)
*
Insrtm1Khn/Insrtm1Dac
Tg(Ckmm-cre)5Khn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory