About Help FAQ

Symbol
Name
ID

Ins2
insulin II
MGI:96573

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased level of 1,5 anhydroglucitol in serum	Reduced C-peptide level	Elevated circulating hepatic transaminase concentration	Hyperglycemia	Diabetes mellitus	Diabetic ketoacidosis	Maturity-onset diabetes of the young	Type I diabetes mellitus	Type II diabetes mellitus	Insulin resistance	Ketoacidosis
Disease(s) Associated with INS	Decreased level of 1,5 anhydroglucitol in serum	Reduced C-peptide level	Elevated circulating hepatic transaminase concentration	Hyperglycemia	Diabetes mellitus	Diabetic ketoacidosis	Maturity-onset diabetes of the young	Type I diabetes mellitus	Type II diabetes mellitus	Insulin resistance	Ketoacidosis
maturity-onset diabetes of the young type 10
pancreatic cancer
permanent neonatal diabetes mellitus
type 1 diabetes mellitus
type 1 diabetes mellitus 2
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased insulin secretion

increased insulin secretion

abnormal homeostasis

increased circulating glucose level

hyperglycemia

decreased circulating insulin level

decreased circulating leptin level

decreased circulating triglyceride level

increased energy expenditure

increased carbon dioxide production

increased oxygen consumption

decreased respiratory quotient

abnormal glucose homeostasis

impaired glucose tolerance

increased urine glucose level

increased insulin sensitivity

insulin resistance

decreased liver triglyceride level

decreased skeletal muscle triglyceride level

albuminuria

Availability

Mouse Genotype

Ins2^Akita/Ins2^Akita

Ins2^C95S/Ins2^C95S

Ins2^{tm1(cre/ERT2)Kcmm}/Ins2^{tm1(cre/ERT2)Kcmm}

*

Ins2^tm1Jja/Ins2^tm1Jja

Ins2^tm1Rll/Ins2^tm1Rll

*

Ins1^{tm1.1(cre)Thor}/Ins1⁺

*

Ins2^Akita/Ins2⁺

*

Ins2^C95S/Ins2⁺

Ins2^em#Arak/Ins2⁺

Ins2^Akita/?

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23