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interleukin 10
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of the immune system
Disease(s) Associated with IL10
rheumatoid arthritis

Mouse Phenotypes
immune system phenotype
decreased T cell proliferation
increased susceptibility to induced colitis
intestinal inflammation
large intestinal inflammation
cecum inflammation
small intestinal inflammation
peritoneal inflammation
increased thymus weight
thymus hyperplasia
pancreas inflammation
abnormal myelopoiesis
increased granulocyte number
increased myeloid dendritic cell number
abnormal lymphocyte cell number
increased plasma cell number
increased B cell number
increased CD4-positive, alpha beta T cell number
increased T cell number
abnormal leukocyte morphology
abnormal myeloid leukocyte morphology
decreased spleen iron level
decreased spleen red pulp amount
spleen hyperplasia
increased IgE level
increased IgG1 level
increased IgG2a level
abnormal CD8-positive, alpha-beta T cell physiology
abnormal regulatory T cell physiology
increased circulating interferon-gamma level
increased circulating interleukin-1 alpha level
increased circulating interleukin-1 beta level
decreased circulating interleukin-10 level
increased circulating interleukin-12 level
abnormal circulating interleukin-12b level
increased circulating interleukin-17 level
increased circulating interleukin-2 level
abnormal circulating interleukin-6 level
increased circulating interleukin-6 level
increased circulating tumor necrosis factor level
abnormal cytokine level
abnormal chemokine level
abnormal interferon level
abnormal interleukin level
abnormal tumor necrosis factor level
abnormal lymph node morphology
abnormal immune system physiology
abnormal Langerhans cell physiology
abnormal type IV hypersensitivity reaction
increased susceptibility to type IV hypersensitivity reaction
abnormal level of surface class II molecules
abnormal hypersensitivity reaction
abnormal cytokine secretion
increased interferon-gamma secretion
decreased interleukin-10 secretion
abnormal inflammatory response
increased susceptibility to endotoxin shock
chronic inflammation
liver inflammation
lung inflammation
abnormal innate immunity
abnormal response to infection
increased susceptibility to bacterial infection
decreased susceptibility to parasitic infection
increased susceptibility to parasitic infection
decreased length of allograft survival
Availability Mouse Genotype
Il10tm1Cgn/Il10tm1Cgn *
Tg(Cd4-cre)1Cwi/0  (conditional)
Foxp3tm4(YFP/icre)Ayr/Y  (conditional)
Il10tm1Roer/Il10tm1Roer  (conditional)
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Tg(Cd4-cre)1Cwi/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory