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Symbol
Name
ID
Igh
immunoglobulin heavy chain complex
MGI:96442
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
increased B cell apoptosis
abnormal B cell proliferation
increased B cell proliferation
insulitis
abnormal B cell differentiation
abnormal class switch recombination
decreased immature B cell number
absent pre-B cells
decreased transitional stage B cell number
decreased transitional stage T2 B cell number
abnormal immunoglobulin V(D)J recombination
abnormal immunoglobulin heavy chain V(D)J recombination
abnormal immunoglobulin light chain V-J recombination
increased early pro-B cell number
abnormal late pro-B cell
increased late pro-B cell number
increased pro-B cell number
abnormal somatic hypermutation frequency
arrested B cell differentiation
abnormal B cell number
decreased mature B cell number
absent mature B cells
absent B-1 B cells
absent B-1a cells
absent B-1b cells
absent follicular B cells
absent marginal zone B cells
absent plasma cells
decreased B-1a cell number
decreased B-1b cell number
decreased follicular B cell number
decreased marginal zone B cell number
increased marginal zone B cell number
decreased B cell number
absent B cells
decreased pre-B cell number
increased B cell number
increased pre-B cell number
abnormal B cell morphology
abnormal mature B cell morphology
abnormal B-1 B cell morphology
abnormal marginal zone B cell morphology
abnormal spleen morphology
spleen hypoplasia
absent spleen germinal center
abnormal B cell physiology
abnormal B cell activation
abnormal immunoglobulin level
decreased IgA level
increased IgA level
decreased IgD level
decreased IgE level
increased IgE level
decreased IgG1 level
increased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG3 level
increased IgG3 level
decreased IgG level
increased IgG level
decreased IgM level
increased IgM level
decreased immunoglobulin level
abnormal marginal zone B cell physiology
abnormal gut-associated lymphoid tissue morphology
abnormal Peyer's patch germinal center morphology
abnormal lymph node germinal center morphology
abnormal immune system physiology
abnormal humoral immune response
increased susceptibility to autoimmune diabetes
increased anti-nuclear antigen antibody level
increased anti-single stranded DNA antibody level
Availability Mouse Genotype
IghdeltaD/IghdeltaD
Ightm1.1Hmj/Ightm1.1Hmj *
Ightm1.1Hws/Ightm1.1Hws
Ightm1.1Rsky/Ightm1.1Rsky
Ightm1.1Twin/Ightm1.1Twin *
Ightm1.1Vmd/Ightm1.1Vmd *
Ightm1.2Rsky/Ightm1.2Rsky
Ightm1Aak/Ightm1Aak
Ightm1Cog/Ightm1Cog
Ightm1Emo/Ightm1Emo *
Ightm1Ktom/Ightm1Ktom
Ightm1Mnz/Ightm1Mnz
Ightm2.1Fwa/Ightm2.1Fwa *
Ightm2.1Hws/Ightm2.1Hws
Ightm2Cog/Ightm2Cog
Ightm2Emo/Ightm2Emo
Ightm2Mnz/Ightm2Mnz
Ightm3.1Cog/Ightm3.1Cog *
Ightm3Cgn/Ightm3Cgn
Ightm3Hws/Ightm3Hws
Ightm4.1Cog/Ightm4.1Cog *
Ightm4.1Fwa/Ightm4.1Fwa
Ightm5.1Cgn/Ightm5.1Cgn
Ightm5.1Cog/Ightm5.1Cog
Ightm5.1Fwa/Ightm5.1Fwa *
Ightm5Cgn/Ightm5Cgn
Ightm6Fwa/Ightm6Fwa *
Ightm7.1Fwa/Ightm7.1Fwa *
Ightm11.1Cgn/Ightm11.1Cgn
Ightm12Cgn/Ightm12Cgn
IghdeltaD/Igh+
Ightm1.1Lnit/Igh+
Ightm1.1Twin/Igh+
Ightm1.1Vmd/Igh+
Ightm1.2Rsky/Igh+
Ightm1Cgn/Igh+
Ightm1Cgn/Ightm2Cgn
Ightm1Kplm/Igh+
Ightm1Kplm/Ightm3Cgn
Ightm1Kplm/Ightm4Cgn
Ightm1Rbr/Igh+
Ightm2Cgn/Igh+
Ightm2Cgn/Ightm3Cgn
Ightm2Cgn/Ightm4.1Fwa
Ightm2Cog/Igh+
Ightm3Cgn/Igh+
Ightm3Mnz/Ightm4.1Mnz *
Ightm4.1Fwa/Igh+
Ightm4Cgn/Igh+
Ightm5.1Fwa/Igh+ *
Ightm7(VHB1-8)Cgn/Igh+
Ightm8(VHB1-8)Cgn/Igh+
Ightm9(VHB1-8)Cgn/Igh+
Tg(Igh3H9)41Mwg/?
Tg(Igh-3VD93)343Ust/?
Tg(IghH280)48Dvs/?
Ightm1.2Rsky/Ightm1.2Rsky
Tg(CD19-cre/ERT2)1Cgn/?  (conditional)
Ightm5Cgn/Ightm5Cgn
Tg(CD19-cre/ERT2)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory