Symbol
Name
ID

Igf1
insulin-like growth factor 1
MGI:96432

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased level of 1,5 anhydroglucitol in serum	Elevated circulating hepatic transaminase concentration	Hyperglycemia	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance	Ketoacidosis
Disease(s) Associated with IGF1	Decreased level of 1,5 anhydroglucitol in serum	Elevated circulating hepatic transaminase concentration	Hyperglycemia	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance	Ketoacidosis
pancreatic cancer
type 1 diabetes mellitus
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased circulating glucose level

increased circulating insulin level

decreased circulating insulin-like growth factor I level

increased circulating leptin level

decreased circulating growth hormone level

increased circulating growth hormone level

abnormal glucose homeostasis

increased urine potassium level

increased urine sodium level

insensitivity to growth hormone

Availability

Mouse Genotype

Igf1^tm1.1Dlr/Igf1^tm1.1Dlr

Igf1^tm1.1Nros/Igf1^tm1.1Nros

Igf1^tm1Arge/Igf1^tm1Arge

Igf1^tm2.1Arge/Igf1^tm2.1Arge

Igf1^tm2Arge/Igf1^tm2Arge

Igf1^tm2Ts/Igf1^tm2Ts

Igf1^tm2Arge/Igf1^tm2.1Arge

Igf1^tm1Dlr/Igf1^tm1Dlr
Tg(Mx1-cre)1Cgn/0 (conditional)

Igf1^tm1Dlr/Igf1^tm1Dlr
Tg(Alb1-cre)1Dlr/0 (conditional)

Igf1^tm1Dlr/Igf1^tm1Dlr
Tg(Serpina1e-cre/ERT)1Sykr/0 (conditional)

Igf1^tm2Arge/Igf1^tm2Arge
Tg(SERPINA1-cre)1Arge/0 (conditional)

Igf1^tm2Arge/Igf1^tm2.1Arge
Tg(SERPINA1-cre)1Arge/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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