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interferon regulatory factor 8
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
increased transitional stage B cell number
abnormal myelopoiesis
increased neutrophil cell number
increased granulocyte number
decreased follicular B cell number
increased mature B cell number
increased B-1b cell number
increased B-2 B cell number
increased follicular B cell number
increased marginal zone B cell number
decreased B cell number
increased B cell number
decreased T cell number
decreased lymphocyte cell number
increased lymphocyte cell number
decreased macrophage cell number
increased macrophage cell number
decreased monocyte cell number
increased leukocyte cell number
abnormal plasma cell number
increased spleen red pulp amount
enlarged spleen
spleen hyperplasia
abnormal spleen marginal zone morphology
increased immunoglobulin level
abnormal cytotoxic T cell physiology
enlarged lymph nodes
abnormal humoral immune response
abnormal interferon secretion
decreased interferon-gamma secretion
increased susceptibility to viral infection
Availability Mouse Genotype
Irf8tm1.1Hm/Irf8tm1.1Hm  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory